FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044188743> ?p ?o ?g. }

• W2044188743 endingPage "726" @default.
• W2044188743 startingPage "720" @default.
• W2044188743 abstract "The prevalence of osteoarthritis (OAs) increases with age and coincides with the accumulation of advanced glycation endproducts (AGEs) in articular cartilage, suggesting that accumulation of glycation products may be involved in the development of OA. This study was designed to examine the effects of accumulation of AGEs on the turnover of the extracellular matrix of human articular cartilage.Chondrocyte mediated cartilage degradation (GAG release, colorimetric) was measured in human articular cartilage of donors aged 19-82 years (N=30, 4-day culture). In addition, to mimic the age-related increase in AGE levels in vitro, cartilage was cultured in the absence or presence of glucose, ribose or threose. Cartilage degradation and proteoglycan synthesis ((35)SO(2)(-4) incorporation) were measured and related to the degree of cartilage AGE levels (fluorescence at 360/460 nm).Chondrocyte-mediated degradation of articular cartilage (i.e. GAG release) decreased with increasing age of the cartilage donor (r=-0.43, P< 0.02). In vitro incubation of cartilage with glucose, ribose or threose resulted in a range of AGE levels that was highly correlated to the chondrocyte-mediated cartilage degradation (r=-0.77, P< 0.001, N=26). In addition, in these in vitro glycated cartilage samples, a decrease in proteoglycan synthesis was observed at increasing AGE levels (r=-0.54, P< 0.005, N=25).This study shows that an increase in AGE levels negatively affects the proteoglycan synthesis and degradation of articular cartilage. In combination, these two effects reduce the turnover of the cartilage and thereby the maintenance and repair capacity of the tissue. By this mechanism, the age-related increase in cartilage AGE levels may contribute to the development of OA." @default.
• W2044188743 created "2016-06-24" @default.
• W2044188743 creator A5017043157 @default.
• W2044188743 creator A5020643810 @default.
• W2044188743 creator A5022435053 @default.
• W2044188743 creator A5030404089 @default.
• W2044188743 creator A5063928355 @default.
• W2044188743 creator A5071144290 @default.
• W2044188743 creator A5085086019 @default.
• W2044188743 creator A5085468214 @default.
• W2044188743 date "2001-11-01" @default.
• W2044188743 modified "2023-09-27" @default.
• W2044188743 title "Accumulation of advanced glycation endproducts reduces chondrocyte-mediated extracellular matrix turnover in human articular cartilage" @default.
• W2044188743 cites W1532082751 @default.
• W2044188743 cites W1552444104 @default.
• W2044188743 cites W1557253076 @default.
• W2044188743 cites W1841004874 @default.
• W2044188743 cites W1966132868 @default.
• W2044188743 cites W1969470371 @default.
• W2044188743 cites W1970200465 @default.
• W2044188743 cites W1976068063 @default.
• W2044188743 cites W1984395266 @default.
• W2044188743 cites W1991163906 @default.
• W2044188743 cites W2000937688 @default.
• W2044188743 cites W2001952131 @default.
• W2044188743 cites W2008729040 @default.
• W2044188743 cites W2017528738 @default.
• W2044188743 cites W2023991682 @default.
• W2044188743 cites W2025035446 @default.
• W2044188743 cites W2026793130 @default.
• W2044188743 cites W2033890820 @default.
• W2044188743 cites W2043397658 @default.
• W2044188743 cites W2052165043 @default.
• W2044188743 cites W2053357515 @default.
• W2044188743 cites W2053538354 @default.
• W2044188743 cites W2054221638 @default.
• W2044188743 cites W2057107933 @default.
• W2044188743 cites W2067377927 @default.
• W2044188743 cites W2069187544 @default.
• W2044188743 cites W2069589041 @default.
• W2044188743 cites W2075800553 @default.
• W2044188743 cites W2077034296 @default.
• W2044188743 cites W2077088113 @default.
• W2044188743 cites W2077741258 @default.
• W2044188743 cites W2107516773 @default.
• W2044188743 cites W2109028819 @default.
• W2044188743 cites W2119538833 @default.
• W2044188743 cites W2120105120 @default.
• W2044188743 cites W2122883560 @default.
• W2044188743 cites W2135152840 @default.
• W2044188743 cites W2147789746 @default.
• W2044188743 cites W2151080115 @default.
• W2044188743 cites W2337292567 @default.
• W2044188743 cites W4240373434 @default.
• W2044188743 cites W4241343866 @default.
• W2044188743 cites W4245734342 @default.
• W2044188743 cites W4248143792 @default.
• W2044188743 cites W99384801 @default.
• W2044188743 doi "https://doi.org/10.1053/joca.2001.0469" @default.
• W2044188743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11795991" @default.
• W2044188743 hasPublicationYear "2001" @default.
• W2044188743 type Work @default.
• W2044188743 sameAs 2044188743 @default.
• W2044188743 citedByCount "103" @default.
• W2044188743 countsByYear W20441887432012 @default.
• W2044188743 countsByYear W20441887432013 @default.
• W2044188743 countsByYear W20441887432014 @default.
• W2044188743 countsByYear W20441887432015 @default.
• W2044188743 countsByYear W20441887432016 @default.
• W2044188743 countsByYear W20441887432017 @default.
• W2044188743 countsByYear W20441887432018 @default.
• W2044188743 countsByYear W20441887432019 @default.
• W2044188743 countsByYear W20441887432020 @default.
• W2044188743 countsByYear W20441887432021 @default.
• W2044188743 countsByYear W20441887432022 @default.
• W2044188743 countsByYear W20441887432023 @default.
• W2044188743 crossrefType "journal-article" @default.
• W2044188743 hasAuthorship W2044188743A5017043157 @default.
• W2044188743 hasAuthorship W2044188743A5020643810 @default.
• W2044188743 hasAuthorship W2044188743A5022435053 @default.
• W2044188743 hasAuthorship W2044188743A5030404089 @default.
• W2044188743 hasAuthorship W2044188743A5063928355 @default.
• W2044188743 hasAuthorship W2044188743A5071144290 @default.
• W2044188743 hasAuthorship W2044188743A5085086019 @default.
• W2044188743 hasAuthorship W2044188743A5085468214 @default.
• W2044188743 hasBestOaLocation W20441887431 @default.
• W2044188743 hasConcept C105702510 @default.
• W2044188743 hasConcept C126322002 @default.
• W2044188743 hasConcept C134018914 @default.
• W2044188743 hasConcept C142724271 @default.
• W2044188743 hasConcept C147990577 @default.
• W2044188743 hasConcept C16685009 @default.
• W2044188743 hasConcept C170493617 @default.
• W2044188743 hasConcept C185592680 @default.
• W2044188743 hasConcept C189165786 @default.
• W2044188743 hasConcept C202751555 @default.
• W2044188743 hasConcept C204787440 @default.
• W2044188743 hasConcept C2776164576 @default.

• next