FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044191529> ?p ?o ?g. }

• W2044191529 endingPage "217" @default.
• W2044191529 startingPage "209" @default.
• W2044191529 abstract "To elucidate the pathophysiological significance of adenosine 3'-monophosphate (3'-AMP) forming enzyme in mice, the effect of streptozotocin (STZ) on the enzyme activities and adenine nucleotide levels in the ICR mice (4-week-old) liver was examined. After 2 weeks, treatment with a single dosage of STZ (100, 150 or 200 mg/kg i.p.) induced a dose-dependent hyperglycemia and hypoinsulinemia but had no effect on serum alanine aminotransferase activity, indicating that STZ generated type 1 diabetes without hepatitis. In the diabetic liver, the activities of superoxide dismutase (SOD), catalase and ATP levels decreased, and the microsomal CYP2E1 activity increased. Changes of these biological activities might disrupt the cellular homeostatic balance of reactive oxygen species (ROS) production. The activities of 3'-AMP forming enzyme, one of the ribonucleases, in hepatic homogenates were not altered. However, in the STZ 200 mg/kg group, the cytosolic forming enzyme activities were enhanced, and inversely, the mitochondrial activity was reduced significantly, indicating that the decrease in the mitochondrial activity may be accelerated by development of diabetes due to the decrease in the antioxidant defense system and/or increase in ROS production. With the decrease in the 3'-AMP forming enzyme activity, the levels of 3'-AMP, a P-site inhibitor of adenylate cyclase, in mitochondrial were significantly reduced. These results obtained suggested that change in the mitochondrial 3'-AMP forming enzyme activity might reflect the pathophysiological change of mitochondrial function with the development of diabetes. Our results also suggested that change in cytosolic enzyme activity might serve as a new biomarker of oxidative stress because significant negative correlation between the activities of cytosolic 3'-AMP forming enzyme and SOD was found in the early stage of diabetes." @default.
• W2044191529 created "2016-06-24" @default.
• W2044191529 creator A5036974880 @default.
• W2044191529 creator A5046776814 @default.
• W2044191529 creator A5056152380 @default.
• W2044191529 creator A5060753858 @default.
• W2044191529 date "2008-01-01" @default.
• W2044191529 modified "2023-09-27" @default.
• W2044191529 title "Hepatic changes in adenine nucleotide levels and adenosine 3'-monophosphate forming enzyme in streptozotocin-induced diabetic mice" @default.
• W2044191529 cites W1509760380 @default.
• W2044191529 cites W1801184284 @default.
• W2044191529 cites W1965634002 @default.
• W2044191529 cites W1970077272 @default.
• W2044191529 cites W1971711301 @default.
• W2044191529 cites W1982070143 @default.
• W2044191529 cites W1989532067 @default.
• W2044191529 cites W1989846327 @default.
• W2044191529 cites W1995477524 @default.
• W2044191529 cites W2014844787 @default.
• W2044191529 cites W2022871709 @default.
• W2044191529 cites W2025353298 @default.
• W2044191529 cites W2028206371 @default.
• W2044191529 cites W2034858334 @default.
• W2044191529 cites W2059920348 @default.
• W2044191529 cites W2063120909 @default.
• W2044191529 cites W2068396499 @default.
• W2044191529 cites W2071598466 @default.
• W2044191529 cites W2084296888 @default.
• W2044191529 cites W2089958501 @default.
• W2044191529 cites W2101894292 @default.
• W2044191529 cites W2114647345 @default.
• W2044191529 cites W2128635872 @default.
• W2044191529 cites W2142081783 @default.
• W2044191529 cites W2142955153 @default.
• W2044191529 cites W2327896700 @default.
• W2044191529 cites W3023211482 @default.
• W2044191529 cites W4205407119 @default.
• W2044191529 doi "https://doi.org/10.2131/jts.33.209" @default.
• W2044191529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18544912" @default.
• W2044191529 hasPublicationYear "2008" @default.
• W2044191529 type Work @default.
• W2044191529 sameAs 2044191529 @default.
• W2044191529 citedByCount "18" @default.
• W2044191529 countsByYear W20441915292012 @default.
• W2044191529 countsByYear W20441915292013 @default.
• W2044191529 countsByYear W20441915292014 @default.
• W2044191529 countsByYear W20441915292015 @default.
• W2044191529 countsByYear W20441915292016 @default.
• W2044191529 countsByYear W20441915292020 @default.
• W2044191529 countsByYear W20441915292021 @default.
• W2044191529 countsByYear W20441915292022 @default.
• W2044191529 countsByYear W20441915292023 @default.
• W2044191529 crossrefType "journal-article" @default.
• W2044191529 hasAuthorship W2044191529A5036974880 @default.
• W2044191529 hasAuthorship W2044191529A5046776814 @default.
• W2044191529 hasAuthorship W2044191529A5056152380 @default.
• W2044191529 hasAuthorship W2044191529A5060753858 @default.
• W2044191529 hasBestOaLocation W20441915291 @default.
• W2044191529 hasConcept C104317684 @default.
• W2044191529 hasConcept C126322002 @default.
• W2044191529 hasConcept C134018914 @default.
• W2044191529 hasConcept C181199279 @default.
• W2044191529 hasConcept C185592680 @default.
• W2044191529 hasConcept C2775838275 @default.
• W2044191529 hasConcept C2776151105 @default.
• W2044191529 hasConcept C2776991684 @default.
• W2044191529 hasConcept C2778979269 @default.
• W2044191529 hasConcept C2779280383 @default.
• W2044191529 hasConcept C2779876172 @default.
• W2044191529 hasConcept C28212737 @default.
• W2044191529 hasConcept C2994266630 @default.
• W2044191529 hasConcept C512185932 @default.
• W2044191529 hasConcept C55493867 @default.
• W2044191529 hasConcept C555293320 @default.
• W2044191529 hasConcept C71924100 @default.
• W2044191529 hasConcept C86803240 @default.
• W2044191529 hasConceptScore W2044191529C104317684 @default.
• W2044191529 hasConceptScore W2044191529C126322002 @default.
• W2044191529 hasConceptScore W2044191529C134018914 @default.
• W2044191529 hasConceptScore W2044191529C181199279 @default.
• W2044191529 hasConceptScore W2044191529C185592680 @default.
• W2044191529 hasConceptScore W2044191529C2775838275 @default.
• W2044191529 hasConceptScore W2044191529C2776151105 @default.
• W2044191529 hasConceptScore W2044191529C2776991684 @default.
• W2044191529 hasConceptScore W2044191529C2778979269 @default.
• W2044191529 hasConceptScore W2044191529C2779280383 @default.
• W2044191529 hasConceptScore W2044191529C2779876172 @default.
• W2044191529 hasConceptScore W2044191529C28212737 @default.
• W2044191529 hasConceptScore W2044191529C2994266630 @default.
• W2044191529 hasConceptScore W2044191529C512185932 @default.
• W2044191529 hasConceptScore W2044191529C55493867 @default.
• W2044191529 hasConceptScore W2044191529C555293320 @default.
• W2044191529 hasConceptScore W2044191529C71924100 @default.
• W2044191529 hasConceptScore W2044191529C86803240 @default.
• W2044191529 hasIssue "2" @default.
• W2044191529 hasLocation W20441915291 @default.
• W2044191529 hasLocation W20441915292 @default.
• W2044191529 hasOpenAccess W2044191529 @default.

• next