Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044193216> ?p ?o ?g. }
- W2044193216 abstract "The majority of naturally occurring biological and chemical toxins are highly lethal, nonproteinaceous, low molecular weight substances which exert their toxicity through a variety of mechanisms. Their relative small size and extreme in vivo toxicity have hampered the development of protective vaccines. We have investigated the feasibility of anti-idiotype-based vaccines which utilize antibodies for inducing a systemic and protective immunity against the in vivo toxicity of some of these toxic substances. A murine IgG1 monoclonal anti-T-2 mycotoxin antibody protective against mycotoxin toxicity was generated. This antibody was used to produce a second generation monoclonal anti-idiotype antibody which was capable of serologically mimicking the tertiary conformation of the nominal antigen, i.e., T-2 mycotoxin. Administration of the monoclonal anti-idiotype antibody to mice induced a circulating and protective antibody response against the in vitro and in vivo toxicity of T-2 mycotoxin. Antibody-based vaccines may represent the only safe and effective strategy for the design of protective vaccines against small nonproteinaceous toxic compounds whose extreme toxicity prevents their use as safe immunogens. The potential of antibody-based vaccines for producing protective immunity against low molecular weight chemical and biological toxins is discussed." @default.
- W2044193216 created "2016-06-24" @default.
- W2044193216 creator A5054660806 @default.
- W2044193216 creator A5063986694 @default.
- W2044193216 creator A5068076273 @default.
- W2044193216 date "1992-03-01" @default.
- W2044193216 modified "2023-10-16" @default.
- W2044193216 title "Anti-idiotype vaccines in toxicology" @default.
- W2044193216 cites W1491191445 @default.
- W2044193216 cites W1524958560 @default.
- W2044193216 cites W1552052054 @default.
- W2044193216 cites W1595148330 @default.
- W2044193216 cites W1796816418 @default.
- W2044193216 cites W1802069116 @default.
- W2044193216 cites W1830562364 @default.
- W2044193216 cites W1912420873 @default.
- W2044193216 cites W1965293165 @default.
- W2044193216 cites W1968249231 @default.
- W2044193216 cites W1980367397 @default.
- W2044193216 cites W1984090131 @default.
- W2044193216 cites W1987141595 @default.
- W2044193216 cites W1988010627 @default.
- W2044193216 cites W1989604008 @default.
- W2044193216 cites W1996831587 @default.
- W2044193216 cites W1997467451 @default.
- W2044193216 cites W2001178699 @default.
- W2044193216 cites W2002169473 @default.
- W2044193216 cites W2005025930 @default.
- W2044193216 cites W2033249687 @default.
- W2044193216 cites W2046907336 @default.
- W2044193216 cites W2048589644 @default.
- W2044193216 cites W2053802731 @default.
- W2044193216 cites W2060462052 @default.
- W2044193216 cites W2075077207 @default.
- W2044193216 cites W2077193636 @default.
- W2044193216 cites W2080987494 @default.
- W2044193216 cites W2087211220 @default.
- W2044193216 cites W2089598244 @default.
- W2044193216 cites W2095638314 @default.
- W2044193216 cites W2097025796 @default.
- W2044193216 cites W2108205479 @default.
- W2044193216 cites W2123522897 @default.
- W2044193216 cites W2142266215 @default.
- W2044193216 cites W2152818353 @default.
- W2044193216 cites W2160611745 @default.
- W2044193216 cites W2164763143 @default.
- W2044193216 cites W2207496355 @default.
- W2044193216 cites W2341512719 @default.
- W2044193216 cites W2480201224 @default.
- W2044193216 cites W2895981377 @default.
- W2044193216 cites W4211202634 @default.
- W2044193216 doi "https://doi.org/10.1007/bf02591390" @default.
- W2044193216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1633317" @default.
- W2044193216 hasPublicationYear "1992" @default.
- W2044193216 type Work @default.
- W2044193216 sameAs 2044193216 @default.
- W2044193216 citedByCount "13" @default.
- W2044193216 countsByYear W20441932162013 @default.
- W2044193216 countsByYear W20441932162014 @default.
- W2044193216 countsByYear W20441932162019 @default.
- W2044193216 crossrefType "journal-article" @default.
- W2044193216 hasAuthorship W2044193216A5054660806 @default.
- W2044193216 hasAuthorship W2044193216A5063986694 @default.
- W2044193216 hasAuthorship W2044193216A5068076273 @default.
- W2044193216 hasBestOaLocation W20441932161 @default.
- W2044193216 hasConcept C147483822 @default.
- W2044193216 hasConcept C150903083 @default.
- W2044193216 hasConcept C159654299 @default.
- W2044193216 hasConcept C178790620 @default.
- W2044193216 hasConcept C185592680 @default.
- W2044193216 hasConcept C203014093 @default.
- W2044193216 hasConcept C207001950 @default.
- W2044193216 hasConcept C29730261 @default.
- W2044193216 hasConcept C542903549 @default.
- W2044193216 hasConcept C74505204 @default.
- W2044193216 hasConcept C86803240 @default.
- W2044193216 hasConcept C8891405 @default.
- W2044193216 hasConcept C98274493 @default.
- W2044193216 hasConceptScore W2044193216C147483822 @default.
- W2044193216 hasConceptScore W2044193216C150903083 @default.
- W2044193216 hasConceptScore W2044193216C159654299 @default.
- W2044193216 hasConceptScore W2044193216C178790620 @default.
- W2044193216 hasConceptScore W2044193216C185592680 @default.
- W2044193216 hasConceptScore W2044193216C203014093 @default.
- W2044193216 hasConceptScore W2044193216C207001950 @default.
- W2044193216 hasConceptScore W2044193216C29730261 @default.
- W2044193216 hasConceptScore W2044193216C542903549 @default.
- W2044193216 hasConceptScore W2044193216C74505204 @default.
- W2044193216 hasConceptScore W2044193216C86803240 @default.
- W2044193216 hasConceptScore W2044193216C8891405 @default.
- W2044193216 hasConceptScore W2044193216C98274493 @default.
- W2044193216 hasIssue "1-4" @default.
- W2044193216 hasLocation W20441932161 @default.
- W2044193216 hasLocation W20441932162 @default.
- W2044193216 hasOpenAccess W2044193216 @default.
- W2044193216 hasPrimaryLocation W20441932161 @default.
- W2044193216 hasRelatedWork W1756027704 @default.
- W2044193216 hasRelatedWork W1995642728 @default.
- W2044193216 hasRelatedWork W2020859525 @default.
- W2044193216 hasRelatedWork W2030586267 @default.