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• W2044199377 abstract "The objective of this study was to evaluate the effects of two different levels of food restriction on testicular angiogenic activity, microvascularization, tissue growth, and regression, using the rabbit as a study model. The rabbits ( Oryctolagus cuniculus cuniculus ) were randomly assigned to a control group (A, n =5), fed ad libitum , and to groups B ( n =5) and C ( n =5), with two different levels of food restriction. Food restriction was responsible for a 21.2% decrease in body weight in group B and 34.7% in group C. Testis explants were cultured for 24 h and conditioned media were tested for their ability to stimulate mitogenesis of bovine aortic endothelial cells (BAEC). There was an increase in testicular microvascular area and mitogenesis of BAEC in group C rabbits. Despite no change in testicular DNA concentration among groups, food restriction decreased both RNA and protein compared with control. No treatment differences in the percentage of seminiferous tubules filled with all stages of spermatogenesis (spermatogonia, spermatocytes, and spermatids) and spermatozoa, as well as the area occupied by seminiferous tubules, were observed. Nevertheless, serum testosterone was markedly less in group C compared with groups A and B. These results suggest that angiogenesis may play a role in overcoming testicular nutritional impairment in rabbits subjected to food restriction." @default.
• W2044199377 created "2016-06-24" @default.
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• W2044199377 date "2009-03-01" @default.
• W2044199377 modified "2023-09-26" @default.
• W2044199377 title "Testicular angiogenic activity in response to food restriction in rabbits" @default.
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• W2044199377 doi "https://doi.org/10.1530/rep-08-0199" @default.
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