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- W2044199904 abstract "cDNA clones encoding the β‐subunit of the photoreceptor cGMP phosphodiesterase (PDE) were isolated from a human retina library and their sequence was determined. The encoded polypeptide consists of 854 amino acid residues with a calculated molecular mass of 98,416 Da. Alignment of the deduced amino acid sequence with the earlier analysed α‐, β‐ and α'‐subunits of bovine and mouse PDEs demonstrates a high homology. Two overlapping recombinant λ phage clones containing 26 kb of the human PDE β‐subunit gene were isolated from the genomic library. A total nucleotide sequence of exons 4–22 of the PDE β‐subunit gene was established which completely corresponded to the cDNA structure. According to sequence analysis no potential possibility for alternative splicing of the β‐subunit gene was observed between exons 20 and 21 which led to the formation of the β'‐subunit as described for mouse PDE. Polymerase chain reaction (PCR) experiments also confirm the absence of the PDE β'‐subunit in human retina." @default.
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- W2044199904 date "1993-08-02" @default.
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- W2044199904 title "The human rod photoreceptor cGMP phosphodiesterase β-subunit" @default.
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- W2044199904 doi "https://doi.org/10.1016/0014-5793(93)81003-i" @default.
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