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- W2044200046 abstract "Neuronal death induced by a variety of means requires participation of the E2F family of transcription factors. Here, we show that E2F acts as a gene silencer in neurons and that repression of E2F-responsive genes is required for neuronal survival. Moreover, neuronal death evoked by DNA damaging agents or trophic factor withdrawal is characterized by derepression of E2F-responsive genes. Such derepression, rather than direct E2F-promoted gene activation, is required for death. Among the genes that are derepressed in neurons subjected to DNA damage or trophic factor withdrawal are the transcription factors B- and C-myb. Overexpression of B- and C-myb is sufficient to evoke neuronal death. These findings support a model in which E2F-dependent gene repression and derepression play pivotal roles in neuronal survival and death, respectively." @default.
- W2044200046 created "2016-06-24" @default.
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- W2044200046 date "2001-11-01" @default.
- W2044200046 modified "2023-09-23" @default.
- W2044200046 title "Regulation of Neuronal Survival and Death by E2F-Dependent Gene Repression and Derepression" @default.
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- W2044200046 doi "https://doi.org/10.1016/s0896-6273(01)00495-0" @default.
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