FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044201957> ?p ?o ?g. }

• W2044201957 endingPage "22" @default.
• W2044201957 startingPage "11" @default.
• W2044201957 abstract "Sex differences exist in the depressive disorder prevalence and response to treatment. Several studies suggest that females respond better than males to the action of selective serotonin reuptake inhibitors (SSRIs), suggesting that gonadal hormones modulate mood and the response to these drugs. Sexual steroid hormones exert organizational actions (perennial and on early development) and activational effects (transient and on differentiated tissues). The aim of this study was to analyze sex differences in the forced swim test (FST) in animals without treatment and after fluoxetine (FLX, 0, 2.5, 5.0 and 10.0mg/kg). Initially, we compared male and female adult rats under control conditions or after altering their sexual differentiation process (at day 5 postnatally, PN, 60μg of testosterone propionate to females and male castration to induce or preclude masculinization, respectively). To further analyze if the sex differences depend on organizational or activational steroid hormone action we tested the same animals before and after adult gonadectomy. To prevent variations depending upon the estrous cycle, control and masculinized females were tested in estrus. Control females showed lower immobility and required lower doses of FLX (5mg/kg), to show an antidepressant-like effect, than males (10mg/kg), even after adult gonadectomy. In control males adult orchidectomy prevented FLX's action. Neonatally masculinized females exhibited analogous levels of immobility than control ones; before ovariectomy they responded to FLX similar to controls, but after the surgery they did not respond to fluoxetine. Neonatally orchidectomized males exhibited similar immobility values and response to FLX than control females. The findings suggest that the sex difference in despair depends on the hormones organizational effects and, in males, the response to FLX relies on organizational and activational actions." @default.
• W2044201957 created "2016-06-24" @default.
• W2044201957 creator A5019886349 @default.
• W2044201957 creator A5049435385 @default.
• W2044201957 creator A5056907912 @default.
• W2044201957 creator A5060627874 @default.
• W2044201957 date "2014-03-01" @default.
• W2044201957 modified "2023-10-16" @default.
• W2044201957 title "Influence of the brain sexual differentiation process on despair and antidepressant-like effect of fluoxetine in the rat forced swim test" @default.
• W2044201957 cites W1902957308 @default.
• W2044201957 cites W1967421959 @default.
• W2044201957 cites W1967768051 @default.
• W2044201957 cites W1970563837 @default.
• W2044201957 cites W1971510748 @default.
• W2044201957 cites W1981144964 @default.
• W2044201957 cites W1993005101 @default.
• W2044201957 cites W1995767136 @default.
• W2044201957 cites W1995846814 @default.
• W2044201957 cites W2003897770 @default.
• W2044201957 cites W2004335091 @default.
• W2044201957 cites W2010537971 @default.
• W2044201957 cites W2010869612 @default.
• W2044201957 cites W2013484791 @default.
• W2044201957 cites W2017201333 @default.
• W2044201957 cites W2020669235 @default.
• W2044201957 cites W2023414423 @default.
• W2044201957 cites W2024240021 @default.
• W2044201957 cites W2024376065 @default.
• W2044201957 cites W2026081258 @default.
• W2044201957 cites W2026702399 @default.
• W2044201957 cites W2030804316 @default.
• W2044201957 cites W2034189826 @default.
• W2044201957 cites W2039419866 @default.
• W2044201957 cites W2041849031 @default.
• W2044201957 cites W2052381346 @default.
• W2044201957 cites W2054446044 @default.
• W2044201957 cites W2057288011 @default.
• W2044201957 cites W2057600258 @default.
• W2044201957 cites W2068583076 @default.
• W2044201957 cites W2070279391 @default.
• W2044201957 cites W2070385784 @default.
• W2044201957 cites W2074756898 @default.
• W2044201957 cites W2087501527 @default.
• W2044201957 cites W2090198145 @default.
• W2044201957 cites W2091064555 @default.
• W2044201957 cites W2092114190 @default.
• W2044201957 cites W2106281752 @default.
• W2044201957 cites W2112318911 @default.
• W2044201957 cites W2116745854 @default.
• W2044201957 cites W2131830842 @default.
• W2044201957 cites W2137296158 @default.
• W2044201957 cites W2138581472 @default.
• W2044201957 cites W2139026473 @default.
• W2044201957 cites W2143550478 @default.
• W2044201957 cites W2148256999 @default.
• W2044201957 cites W2150303699 @default.
• W2044201957 cites W2159116451 @default.
• W2044201957 cites W2161678767 @default.
• W2044201957 doi "https://doi.org/10.1016/j.neuroscience.2013.12.035" @default.
• W2044201957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24374081" @default.
• W2044201957 hasPublicationYear "2014" @default.
• W2044201957 type Work @default.
• W2044201957 sameAs 2044201957 @default.
• W2044201957 citedByCount "32" @default.
• W2044201957 countsByYear W20442019572014 @default.
• W2044201957 countsByYear W20442019572015 @default.
• W2044201957 countsByYear W20442019572016 @default.
• W2044201957 countsByYear W20442019572017 @default.
• W2044201957 countsByYear W20442019572018 @default.
• W2044201957 countsByYear W20442019572019 @default.
• W2044201957 countsByYear W20442019572020 @default.
• W2044201957 countsByYear W20442019572021 @default.
• W2044201957 countsByYear W20442019572022 @default.
• W2044201957 countsByYear W20442019572023 @default.
• W2044201957 crossrefType "journal-article" @default.
• W2044201957 hasAuthorship W2044201957A5019886349 @default.
• W2044201957 hasAuthorship W2044201957A5049435385 @default.
• W2044201957 hasAuthorship W2044201957A5056907912 @default.
• W2044201957 hasAuthorship W2044201957A5060627874 @default.
• W2044201957 hasConcept C104317684 @default.
• W2044201957 hasConcept C126322002 @default.
• W2044201957 hasConcept C134018914 @default.
• W2044201957 hasConcept C136569192 @default.
• W2044201957 hasConcept C15744967 @default.
• W2044201957 hasConcept C170493617 @default.
• W2044201957 hasConcept C1998276 @default.
• W2044201957 hasConcept C2775864247 @default.
• W2044201957 hasConcept C2776134451 @default.
• W2044201957 hasConcept C2777911890 @default.
• W2044201957 hasConcept C2779177272 @default.
• W2044201957 hasConcept C2779256933 @default.
• W2044201957 hasConcept C2779279991 @default.
• W2044201957 hasConcept C2781115071 @default.
• W2044201957 hasConcept C2781161787 @default.
• W2044201957 hasConcept C55493867 @default.
• W2044201957 hasConcept C63405245 @default.
• W2044201957 hasConcept C71315377 @default.
• W2044201957 hasConcept C71924100 @default.

• next