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- W2044202230 abstract "A standard of therapy for osteosarcoma includes amputation with or without adjuvant chemotherapy. There is a subset of dogs with osteosarcoma that are unsuitable for amputation. We evaluated kinetic variables in dogs with appendicular osteosarcoma treated with a single 8 Gy dose of radiation. Eighteen pet dogs with appendicular osteosarcoma received one 8 Gy fraction of palliative radiation on day 0. Force plate measurements and clinical assessments were made on days 0, 7, 14, and 21. Peak vertical forces ( F z ) were recorded for each limb and a symmetric index (SI) was calculated. There were no significant changes in kinetic parameters after one 8 Gy dose of radiation therapy. Nine of these 18 dogs exhibited increased limb function at day 21 based on force plate analysis. Significant factors affecting F z included gender and tumor location. There was a significant correlation between F z and response to therapy based on SI at day 21. SI seems to be useful to objectively assess response in this mixed population of dogs. One 8 Gy fraction of radiation therapy alone did not reduce lameness associated with appendicular osteosarcoma, but a subset of dogs did have improved limb function after a single dose." @default.
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- W2044202230 date "2009-10-26" @default.
- W2044202230 modified "2023-10-18" @default.
- W2044202230 title "USE OF FORCE PLATE ANALYSIS TO EVALUATE THE EFFICACY OF EXTERNAL BEAM RADIATION TO ALLEVIATE OSTEOSARCOMA PAIN" @default.
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- W2044202230 doi "https://doi.org/10.1111/j.1740-8261.2009.01602.x" @default.
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