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- W2044202287 abstract "Abstract Isometric contraction of stratum corneum during heating in water revealed differences between normals and some patients with inherited disorders of keratinization. The palmar scales in patients with ichthyosis vulgaris, lamellar ichthyosis, and keratosis palmaris et plantaris contracted when heated without prior extraction with polar organic solvents; normal palmar stratum corneum requires prior extraction before contraction. In these diseases the scales from the general body epidermis were not different from normal stratum corneum or intraepidermal blister tops. X-ray diffraction analysis of these tissues before and after contraction showed the same changes in the fibrous proteins as occur in normal stratum corneum during contraction. The data suggest that the α-fibrous protein itself is normal in these diseases but that there is an alteration in the sequence of maturation which occur in the stratum corneum. Similar studies from the blisters of patients with dominant and recessive dystrophic epidermolysis bullosa revealed no abnormalities. The failure of stratum corneum from the harlequin fetus to contract even after organic solvent extraction further supports the hypothesis that the conformational change of the fibrous proteins from alpha to beta is responsible for epidermal contraction." @default.
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- W2044202287 date "1972-02-01" @default.
- W2044202287 modified "2023-09-26" @default.
- W2044202287 title "Thermal denaturation of epidermis from hereditary diseases of keratinization" @default.
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- W2044202287 doi "https://doi.org/10.1016/0014-4800(72)90023-8" @default.
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