Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044202649> ?p ?o ?g. }
- W2044202649 endingPage "10" @default.
- W2044202649 startingPage "1" @default.
- W2044202649 abstract "Diabetes mellitus has been reported to affect functions of the hippocampus. We hypothesized that Centella asiatica, a herb traditionally being used to improve memory, prevents diabetes-related hippocampal dysfunction. Therefore, the aim of this study was to investigate the protective role of C. asiatica on the hippocampus in diabetes. Methods. Streptozotocin- (STZ-) induced adult male diabetic rats received 100 and 200 mg/kg/day body weight (b.w) C. asiatica leaf aqueous extract for four consecutive weeks. Following sacrifice, hippocampus was removed and hippocampal tissue homogenates were analyzed for Na(+)/K(+)-, Ca(2+)- and Mg(2+)-ATPases activity levels. Levels of the markers of inflammation (tumor necrosis factor, TNF-α; interleukin, IL-6; and interleukin, IL-1β) and oxidative stress (lipid peroxidation product: LPO, superoxide dismutase: SOD, catalase: CAT, and glutathione peroxidase: GPx) were determined. The hippocampal sections were visualized for histopathological changes. Results. Administration of C. asiatica leaf aqueous extract to diabetic rats maintained near normal ATPases activity levels and prevents the increase in the levels of inflammatory and oxidative stress markers in the hippocampus. Lesser signs of histopathological changes were observed in the hippocampus of C. asiatica leaf aqueous extract treated diabetic rats. Conclusions. C. asiatica leaf protects the hippocampus against diabetes-induced dysfunction which could help to preserve memory in this condition." @default.
- W2044202649 created "2016-06-24" @default.
- W2044202649 creator A5004597569 @default.
- W2044202649 creator A5041845594 @default.
- W2044202649 creator A5043767598 @default.
- W2044202649 creator A5050878268 @default.
- W2044202649 creator A5058130347 @default.
- W2044202649 date "2014-01-01" @default.
- W2044202649 modified "2023-10-16" @default.
- W2044202649 title "<i>Centella asiatica</i>Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats" @default.
- W2044202649 cites W108354466 @default.
- W2044202649 cites W1492232967 @default.
- W2044202649 cites W1495523023 @default.
- W2044202649 cites W1529155271 @default.
- W2044202649 cites W1562487113 @default.
- W2044202649 cites W1750690213 @default.
- W2044202649 cites W1775749144 @default.
- W2044202649 cites W1912999573 @default.
- W2044202649 cites W1965225492 @default.
- W2044202649 cites W1969413179 @default.
- W2044202649 cites W1973063801 @default.
- W2044202649 cites W1974556508 @default.
- W2044202649 cites W1974588388 @default.
- W2044202649 cites W1976913935 @default.
- W2044202649 cites W1977689421 @default.
- W2044202649 cites W1987051386 @default.
- W2044202649 cites W1991506895 @default.
- W2044202649 cites W1991857351 @default.
- W2044202649 cites W1998365957 @default.
- W2044202649 cites W1998802978 @default.
- W2044202649 cites W1998803557 @default.
- W2044202649 cites W1999539774 @default.
- W2044202649 cites W2000560458 @default.
- W2044202649 cites W2004310764 @default.
- W2044202649 cites W2005386624 @default.
- W2044202649 cites W2010098510 @default.
- W2044202649 cites W2010397126 @default.
- W2044202649 cites W2024809006 @default.
- W2044202649 cites W2031561250 @default.
- W2044202649 cites W2043110022 @default.
- W2044202649 cites W2050512205 @default.
- W2044202649 cites W2051736421 @default.
- W2044202649 cites W2053139788 @default.
- W2044202649 cites W2053837068 @default.
- W2044202649 cites W2057722042 @default.
- W2044202649 cites W2059606036 @default.
- W2044202649 cites W2060194897 @default.
- W2044202649 cites W2065419663 @default.
- W2044202649 cites W2068448989 @default.
- W2044202649 cites W2071664759 @default.
- W2044202649 cites W2073085454 @default.
- W2044202649 cites W2073940782 @default.
- W2044202649 cites W2076554399 @default.
- W2044202649 cites W2076752309 @default.
- W2044202649 cites W2079351469 @default.
- W2044202649 cites W2079365988 @default.
- W2044202649 cites W2082198711 @default.
- W2044202649 cites W2083949851 @default.
- W2044202649 cites W2089387966 @default.
- W2044202649 cites W2091094196 @default.
- W2044202649 cites W2092082847 @default.
- W2044202649 cites W2099474680 @default.
- W2044202649 cites W2106561300 @default.
- W2044202649 cites W2106828037 @default.
- W2044202649 cites W2153853300 @default.
- W2044202649 cites W2159144764 @default.
- W2044202649 cites W2164082231 @default.
- W2044202649 cites W2175835252 @default.
- W2044202649 cites W969915667 @default.
- W2044202649 cites W1987028868 @default.
- W2044202649 doi "https://doi.org/10.1155/2014/592062" @default.
- W2044202649 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4139016" @default.
- W2044202649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25161691" @default.
- W2044202649 hasPublicationYear "2014" @default.
- W2044202649 type Work @default.
- W2044202649 sameAs 2044202649 @default.
- W2044202649 citedByCount "23" @default.
- W2044202649 countsByYear W20442026492016 @default.
- W2044202649 countsByYear W20442026492017 @default.
- W2044202649 countsByYear W20442026492018 @default.
- W2044202649 countsByYear W20442026492019 @default.
- W2044202649 countsByYear W20442026492020 @default.
- W2044202649 countsByYear W20442026492021 @default.
- W2044202649 countsByYear W20442026492022 @default.
- W2044202649 countsByYear W20442026492023 @default.
- W2044202649 crossrefType "journal-article" @default.
- W2044202649 hasAuthorship W2044202649A5004597569 @default.
- W2044202649 hasAuthorship W2044202649A5041845594 @default.
- W2044202649 hasAuthorship W2044202649A5043767598 @default.
- W2044202649 hasAuthorship W2044202649A5050878268 @default.
- W2044202649 hasAuthorship W2044202649A5058130347 @default.
- W2044202649 hasBestOaLocation W20442026491 @default.
- W2044202649 hasConcept C126322002 @default.
- W2044202649 hasConcept C134018914 @default.
- W2044202649 hasConcept C148762608 @default.
- W2044202649 hasConcept C185592680 @default.
- W2044202649 hasConcept C2775838275 @default.
- W2044202649 hasConcept C2776151105 @default.