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• W2044202871 abstract "Dissolution profiles are classified in accordance with the shape of fractional dissolution rate function. This function is constant in time for the classical first-order model and, in this case, the dissolution is described by a monoexponential function. Therefore, any deviation of the fractional dissolution rate from the constant level suggests the presence of different (nonlinear/nonhomogenous) mechanisms in the dissolution process. The shapes of the fractional dissolution rate depend on the type of the model of dissolution; thus, classification with respect to this function is proposed as a tool for model selection. The Kullback-Leibler information distance is proposed for measuring similarity between two different drug dissolution profiles. The method is applied mainly to compare the first-order model, which characterizes a homogenous dosage form, with other common descriptors of dissolution and with experimental data." @default.
• W2044202871 created "2016-06-24" @default.
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• W2044202871 date "2003-08-01" @default.
• W2044202871 modified "2023-09-25" @default.
• W2044202871 title "Classification of Dissolution Profiles in Terms of Fractional Dissolution Rate and a Novel Measure of Heterogeneity" @default.
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• W2044202871 doi "https://doi.org/10.1002/jps.10419" @default.
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