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- W2044203417 abstract "There are tremendous drug candidates that suffer from insolubility in water. In the present study, it is shown that Coenzyme Q10 (CoQ10), a model water-insoluble compound, can be nanoparticulated into a water-soluble form using apolipoprotein A-I (apoA-I). Similar to the way that apoA-I forms nascent discoidal high density lipoprotein (ndHDL) particles by bordering acyl chain tails of phospholipids, CoQ10 could be enclosed into the circle of a disk made of apoA-Is. The resulting nanostructure of CoQ10 and apoA-I was water-soluble with a size of ∼12 nm in diameter and was physically more robust than liposome. We expect that the strategy suggested in this study can be exploited to assemble nano-sized, water-soluble structures of various water-insoluble drug candidates." @default.
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- W2044203417 date "2009-10-01" @default.
- W2044203417 modified "2023-10-15" @default.
- W2044203417 title "Assembly of Coenzyme Q10 nanostructure resembling nascent discoidal high density lipoprotein particle" @default.
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- W2044203417 doi "https://doi.org/10.1016/j.bbrc.2009.07.140" @default.
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