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- W2044205538 abstract "A significant component of the aging process is genetically determined. Numerous theories of aging exist, many of which postulate the existence of longevity genes. Recent advances in molecular biological and other techniques have allowed a significantly greater understanding of aging and age-related disease. This will be illustrated by four genetic and sporadic diseases: Alzheimer's disease (AD) and related disorders, transthyretin dementia, cerebral amyloid angiopathy-Icelandic type and scrapie related diseases. Alzheimer's disease (AD), the most common of this group, is the leading cause of dementia in Western countries. Recent genetic and biochemical studies have shown the involvement of at least four genes in the pathogenesis of AD. In early-onset familial AD mutations in the beta PP, S182 (presenilin 1) and STM2 (presenilin 2 or E5-1) genes have been found, while in the more common late-onset AD the presence of the apolipoprotein E4 isotype is a major risk factor. Genetic studies have also helped to elucidate the etiology of rarer cerebral amyloidoses such as the recently described Hungarian amyloidosis that is characterized by meningocerebrovascular amyloid deposition, with resultant dementia. This disease is linked to a mutation in the transthyretin gene. It is hoped that in the near future this increase in knowledge will allow the development of therapeutic approaches to slow the aging process." @default.
- W2044205538 created "2016-06-24" @default.
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- W2044205538 date "1996-01-01" @default.
- W2044205538 modified "2023-10-03" @default.
- W2044205538 title "Molecular biology of brain aging and neurodegenerative disorders." @default.
- W2044205538 cites W1518693759 @default.
- W2044205538 cites W1537950723 @default.
- W2044205538 cites W1555517932 @default.
- W2044205538 cites W1571568573 @default.
- W2044205538 cites W1588478093 @default.
- W2044205538 cites W1918115329 @default.
- W2044205538 cites W1965496447 @default.
- W2044205538 cites W1972615369 @default.
- W2044205538 cites W1972706019 @default.
- W2044205538 cites W1973391728 @default.
- W2044205538 cites W1979543098 @default.
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- W2044205538 cites W1991234664 @default.
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- W2044205538 cites W1998028029 @default.
- W2044205538 cites W1999941209 @default.
- W2044205538 cites W2005413578 @default.
- W2044205538 cites W2012293927 @default.
- W2044205538 cites W2013833879 @default.
- W2044205538 cites W2014174528 @default.
- W2044205538 cites W2015654033 @default.
- W2044205538 cites W2015675204 @default.
- W2044205538 cites W2017568059 @default.
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- W2044205538 cites W2024363942 @default.
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- W2044205538 cites W2039482551 @default.
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- W2044205538 cites W2095306729 @default.
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- W2044205538 cites W2115428069 @default.
- W2044205538 cites W2122978471 @default.
- W2044205538 cites W2123869079 @default.
- W2044205538 cites W2139304769 @default.
- W2044205538 cites W2139818289 @default.
- W2044205538 cites W2144665461 @default.
- W2044205538 cites W2152116707 @default.
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- W2044205538 cites W2407526549 @default.
- W2044205538 cites W2765241621 @default.
- W2044205538 cites W99811327 @default.
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