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• W2044206586 abstract "Large osteoclasts (≥10 nuclei) predominate at sites of pathological bone resorption. We hypothesized this was related to increased resorptive activity of large osteoclasts and have demonstrated previously that larger osteoclasts are 8-fold more likely to be resorbing than small osteoclasts (2–5 nuclei). Here we ask whether these differences in resorptive activity can be explained by differences in expression of factors involved in osteoclast signaling, fusion, attachment, and matrix degradation. Authentic rabbit osteoclasts and osteoclasts derived from RAW264.7 cells showed similar increases in c-fms expression (1.7- to 1.8-fold) in large osteoclasts suggesting that RAW cells are a viable system for further analysis. We found 2- to 4.5-fold increases in the expression of the integrins αv and β3, the proteases proMMP9, matMMP9 and pro-cathepsinK, and in activating receptors RANK, IL-1R1, and TNFR1 in large osteoclasts. In contrast, small osteoclasts had higher expression of the fusion protein SIRPα1 and the decoy receptor IL-1R2. The higher expression of activation receptors and lower expression of IL-1R2 in large osteoclasts suggest they are hyperresponsive to extracellular factors. This is supported by the observation that the resorptive activity in large osteoclasts was more responsive to IL-1β, and that this increased activity was inhibited by the IL-1 receptor antagonist, IL-1ra. This increased responsiveness of large osteoclasts to IL-1 may, in part, explain the pathological bone loss noted in inflammatory diseases. The heterogeneity in receptor expression and the differential response to cytokines and their antagonists could prove useful for selective inhibition of large osteoclasts actively engaged in pathological bone loss. J. Cell. Biochem. 101: 205–220, 2007. © 2007 Wiley-Liss, Inc." @default.
• W2044206586 created "2016-06-24" @default.
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• W2044206586 date "2007-01-01" @default.
• W2044206586 modified "2023-10-11" @default.
• W2044206586 title "Increased expression of activating factors in large osteoclasts could explain their excessive activity in osteolytic diseases" @default.
• W2044206586 cites W1501363941 @default.
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• W2044206586 cites W1576773659 @default.
• W2044206586 cites W1593116251 @default.
• W2044206586 cites W1662970451 @default.
• W2044206586 cites W1677043489 @default.
• W2044206586 cites W1964238445 @default.
• W2044206586 cites W1972581358 @default.
• W2044206586 cites W1976578540 @default.
• W2044206586 cites W1979427494 @default.
• W2044206586 cites W1981757045 @default.
• W2044206586 cites W1981884992 @default.
• W2044206586 cites W1988699576 @default.
• W2044206586 cites W2002677640 @default.
• W2044206586 cites W2004354707 @default.
• W2044206586 cites W2005603603 @default.
• W2044206586 cites W2015721537 @default.
• W2044206586 cites W2017741522 @default.
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• W2044206586 cites W2024455527 @default.
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• W2044206586 cites W2028407058 @default.
• W2044206586 cites W2030077822 @default.
• W2044206586 cites W2030103715 @default.
• W2044206586 cites W2033120898 @default.
• W2044206586 cites W2041177539 @default.
• W2044206586 cites W2048515208 @default.
• W2044206586 cites W2049305736 @default.
• W2044206586 cites W2052086314 @default.
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• W2044206586 cites W2069850637 @default.
• W2044206586 cites W2071214502 @default.
• W2044206586 cites W2076963119 @default.
• W2044206586 cites W2076974856 @default.
• W2044206586 cites W2081301424 @default.
• W2044206586 cites W2081636793 @default.
• W2044206586 cites W2087050793 @default.
• W2044206586 cites W2093247789 @default.
• W2044206586 cites W2093252878 @default.
• W2044206586 cites W2094321811 @default.
• W2044206586 cites W2098015378 @default.
• W2044206586 cites W2101840353 @default.
• W2044206586 cites W2104882573 @default.
• W2044206586 cites W2107925338 @default.
• W2044206586 cites W2115044953 @default.
• W2044206586 cites W2118567646 @default.
• W2044206586 cites W2122303350 @default.
• W2044206586 cites W2126047615 @default.
• W2044206586 cites W2130549848 @default.
• W2044206586 cites W2139347911 @default.
• W2044206586 cites W2149275181 @default.
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• W2044206586 doi "https://doi.org/10.1002/jcb.21171" @default.
• W2044206586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17216600" @default.
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