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- W2044207869 abstract "One of the predominant symptoms of early stages of hepatic encephalopathy (HE) is bradykinesia.To further analyze the pathophysiology of bradykinesia in HE.A three-dimensional computer-assisted movement analysis was performed in 36 cirrhotics with grade 0-I HE compared to 18 controls selected with regard to sex and age and 16 patients with Parkinson's disease (PD). Four types of movement were studied: finger tapping, hand tapping, pronation/supination of the forearm and flexion/extension in the hip joint.The patients with PD presented with a decrease of the maximal movement velocity (VMAX) and a prolongation of the time needed to reach VMAX (VTIME). In patients with minimal or grade I HE, the VMAX of all movements was unchanged compared to controls while the VTIME was significantly prolonged. This was caused by a delay before the beginning of each new part of the diadochokinetic movement cycle.The data suggest an impairment of movement initiation as main cause of bradykinesia in early HE." @default.
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- W2044207869 date "2003-03-01" @default.
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- W2044207869 title "Bradykinesia in minimal hepatic encephalopathy is due to disturbances in movement initiation" @default.
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- W2044207869 doi "https://doi.org/10.1016/s0168-8278(02)00423-3" @default.
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