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• W2044218350 endingPage "726" @default.
• W2044218350 startingPage "713" @default.
• W2044218350 abstract "Noradrenaline, acetylcholinesterase, and vasoactive intestinal polypeptide (VIP) were visualized in uterine nerves of cats by histochemical techniques. Alterations were followed in different regions of the organs at various stages of pregnancy and compared with the situation in non-pregnant controls. Positively stained nerve fibres, the adrenergic type being particularly well developed, were found along the muscle bundles and around blood vessels in the smooth muscle layers, as well as in the mucosa, of both uterine horns and cervix. The nerve supply was especially prominent in the upper part of the cervix. The distribution of VIP-immunoreactive and acetylcholinesterase-positive nerve fibres resembled each other, but they were less numerous than the adrenergic fibres. In the course of pregnancy there was a marked reduction in the number of all positively reacting nerves, so that almost no fibres were visible in the uterine horns near term. A small number of positive nerve fibres was found to remain, however, in the wall of the sterile (empty) horn during unilateral pregnancy. The reduction was less prominent in the cervix, particularly its lower part. Distinct changes were encountered already during early and mid pregnancy in those parts of the uterine wall distended by the growing conceptus, where almost no fibres were seen. The nerve supply was more intact in the non-distended portions located between the fetuses, and especially in the empty horn of unilateral pregnancy. No overt reduction in the number of positively stained nerve fibres was found in the cervix at these pregnancy stages. The results show that marked alterations take place in the uterine autonomie innervation during such an entirely physiological event as pregnancy. There is reason to assume that the histochemical observations reflect both structural and functional alterations in the innervation related both to the type of nerves involved and to the localization of the conceptus." @default.
• W2044218350 created "2016-06-24" @default.
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• W2044218350 date "1986-07-01" @default.
• W2044218350 modified "2023-09-24" @default.
• W2044218350 title "Histochemical demonstration of a concomitant reduction in neural vasoactive intestinal polypeptide, acetylcholinesterase, and noradrenaline of cat uterus during pregnancy" @default.
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• W2044218350 doi "https://doi.org/10.1016/0306-4522(86)90065-5" @default.
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