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- W2044218359 abstract "NDIGO CARMINE is a blue dye administered intravenously to detect ureteral injury during surgery. A typical dose of 5 mL of indigo carmine is eliminated rapidly in the urine within 10 minutes of intravenous (IV) administration. Although indigo carmine is believed to have a safe profile without known drug or disease interactions, there have been several case reports of severe hemodynamic instability related to IV administration. 1–9 Hypertension following administration of the dye is well documented 1–3 and is likely related to indigo carmine’s molecular similarity to serotonin. On the other hand, hypotension following administration of indigo carmine is an uncommon event, documented in only a handful of cases. 4–9 The authors present a case of severe hypotension immediately following IV administration of indigo carmine in a parturient with idiopathic pulmonary artery hypertension, hypertrophic cardiomyopathy, and left anterior descending (LAD) artery myocardial bridging. They believe that these comorbidities, combined with the pharmacologic properties of indigo carmine, created an uncommon but severe episode of hypotension in a patient who was otherwise stable during a cesarean hysterectomy for placenta increta. They propose that the unanticipated drop in blood pressure in this case report was a consequence of a temporary decrease in cardiac output secondary to nitric oxide inhibition and/or serotonin-mediated ventricular inotropy." @default.
- W2044218359 created "2016-06-24" @default.
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- W2044218359 date "2016-01-01" @default.
- W2044218359 modified "2023-09-30" @default.
- W2044218359 title "Indigo Carmine-Induced Hypotension in a Parturient With Idiopathic Pulmonary Artery Hypertension, Hypertrophic Cardiomyopathy, and LAD Myocardial Bridging" @default.
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- W2044218359 doi "https://doi.org/10.1053/j.jvca.2015.02.013" @default.
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