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- W2044218862 abstract "Specific receptor binding for IGF's is measurable in younger (lighter) RBC's. An aliquot of such cells of similar age (fraction A), can be reproducibly obtained by dextran gradient centrifugation from 5-10 ml of blood.(JCEM 1983 57: 436). We now report IGF-2 SB to these RBC's from normal children and those with growth hormone deficiency (GH def.). Inter- and intra-assay variability of the procedure is 11%. The per cent of total RBC's in fraction A did not differ in the 2 groups of children. Normals (Group 1), were 5 male volunteers (14.7± .6 yr, Mean and SEM) and 10 children (3 female) with constitutional short stature (11.4± 1.6yrs) who had normal 6 hr GH profiles and plasma IGF-1 values. 11 GH def. children (Group 2), aged 12.7 ± 1.4yr,(6 girls),had samples taken after 2 mos without hGH therapy (2a), and again during 10 mos of hGH (2U,3/wk) (2b). RESULTS: Group 1 had IGF-2 SB of 10.2± 0.6% (per 3×109 cells). IGF-2 SB was less in Group 2a at 6.6±0.8% (P < 0.002). With hGH therapy (2b), IGF-2 SB rose to 10.4±1.0% (P < 0.02), a value not different from that in Group 1. Corresponding plasma IGF-2 values showed a positive correlation with IGF-2 SB (R=0.58, P < 0.01). 3 patients have had a 2nd 2 month interruption of hGH. They had a similar response; off hGH, 6±2.7%: on hGH, 10.6 ±.96%: Thus GH deficiency is associated with a reversible decrease in IGF-2 SB on the RBC. These data suggest that plasma IGF-2 may upregulate its own receptor." @default.
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- W2044218862 date "1985-06-01" @default.
- W2044218862 modified "2023-10-17" @default.
- W2044218862 title "93 INCREASE IN SPECIFIC BINDING (SB) OF ERYTHROCYTE (RBC) RECEPTORS FOR INSULIN-LIKE GROWTH FACTOR 2 (IGF-2) WITH GROWTH HORMONE TREATMENT OF HYPOPITUITARY CHILDREN" @default.
- W2044218862 doi "https://doi.org/10.1203/00006450-198506000-00113" @default.
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