Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044228465> ?p ?o ?g. }
- W2044228465 endingPage "603" @default.
- W2044228465 startingPage "603" @default.
- W2044228465 abstract "Metastasis is the cause of over 90% of all human cancer deaths. Early steps in the metastatic process include: the formation of new blood vessels, the initiation of epithelial-mesenchymal transition (EMT), and the mobilization of tumor cells into the circulation. There are ongoing efforts to replicate the physiological landscape of human tumor tissue using three-dimensional in vitro culture models; however, few systems are able to capture the full range of authentic, complex in vivo events such as neovascularization and intravasation. Here we introduce the Prevascularized Tumor (PVT) model to investigate early events of solid tumor progression. PVT spheroids are composed of endothelial and tumor cells, and are embedded in a fibrin matrix containing fibroblasts. The PVT model facilitates two mechanisms of vessel formation: robust sprouting angiogenesis into the matrix, and contiguous vascularization within the spheroid. Furthermore, the PVT model enables the intravasation of tumor cells that is enhanced under low oxygen conditions and is also dependent on the key EMT transcription factor Slug. The PVT model provides a significant advance in the mimicry of human tumors in vitro, and may improve investigation and targeting of events in the metastatic process." @default.
- W2044228465 created "2016-06-24" @default.
- W2044228465 creator A5014109783 @default.
- W2044228465 creator A5033666255 @default.
- W2044228465 creator A5062359081 @default.
- W2044228465 creator A5075612136 @default.
- W2044228465 creator A5090080497 @default.
- W2044228465 date "2014-01-01" @default.
- W2044228465 modified "2023-09-28" @default.
- W2044228465 title "A three-dimensional in vitro model of tumor cell intravasation" @default.
- W2044228465 cites W1481881961 @default.
- W2044228465 cites W1493975488 @default.
- W2044228465 cites W1520425169 @default.
- W2044228465 cites W1527382852 @default.
- W2044228465 cites W1561178184 @default.
- W2044228465 cites W1573363574 @default.
- W2044228465 cites W1964034024 @default.
- W2044228465 cites W1964081206 @default.
- W2044228465 cites W1971828920 @default.
- W2044228465 cites W1974779941 @default.
- W2044228465 cites W1976115786 @default.
- W2044228465 cites W1979909585 @default.
- W2044228465 cites W1981030985 @default.
- W2044228465 cites W1981915045 @default.
- W2044228465 cites W1985804036 @default.
- W2044228465 cites W1987486152 @default.
- W2044228465 cites W1992195887 @default.
- W2044228465 cites W1997508706 @default.
- W2044228465 cites W2002408287 @default.
- W2044228465 cites W2010251891 @default.
- W2044228465 cites W2013097829 @default.
- W2044228465 cites W2021689192 @default.
- W2044228465 cites W2023338540 @default.
- W2044228465 cites W2033474014 @default.
- W2044228465 cites W2041585886 @default.
- W2044228465 cites W2050280891 @default.
- W2044228465 cites W2054728198 @default.
- W2044228465 cites W2062265555 @default.
- W2044228465 cites W2062809449 @default.
- W2044228465 cites W2064632700 @default.
- W2044228465 cites W2068118297 @default.
- W2044228465 cites W2069593816 @default.
- W2044228465 cites W2071801522 @default.
- W2044228465 cites W2075093878 @default.
- W2044228465 cites W2082775736 @default.
- W2044228465 cites W2088716692 @default.
- W2044228465 cites W2094948118 @default.
- W2044228465 cites W2104108149 @default.
- W2044228465 cites W2111790269 @default.
- W2044228465 cites W2115368694 @default.
- W2044228465 cites W2115859969 @default.
- W2044228465 cites W2117692326 @default.
- W2044228465 cites W2128691891 @default.
- W2044228465 cites W2132892999 @default.
- W2044228465 cites W2133156689 @default.
- W2044228465 cites W2134361367 @default.
- W2044228465 cites W2151478643 @default.
- W2044228465 cites W2155554726 @default.
- W2044228465 cites W2314203153 @default.
- W2044228465 cites W2804842145 @default.
- W2044228465 cites W98420059 @default.
- W2044228465 doi "https://doi.org/10.1039/c3ib40170g" @default.
- W2044228465 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4046910" @default.
- W2044228465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24763498" @default.
- W2044228465 hasPublicationYear "2014" @default.
- W2044228465 type Work @default.
- W2044228465 sameAs 2044228465 @default.
- W2044228465 citedByCount "167" @default.
- W2044228465 countsByYear W20442284652014 @default.
- W2044228465 countsByYear W20442284652015 @default.
- W2044228465 countsByYear W20442284652016 @default.
- W2044228465 countsByYear W20442284652017 @default.
- W2044228465 countsByYear W20442284652018 @default.
- W2044228465 countsByYear W20442284652019 @default.
- W2044228465 countsByYear W20442284652020 @default.
- W2044228465 countsByYear W20442284652021 @default.
- W2044228465 countsByYear W20442284652022 @default.
- W2044228465 countsByYear W20442284652023 @default.
- W2044228465 crossrefType "journal-article" @default.
- W2044228465 hasAuthorship W2044228465A5014109783 @default.
- W2044228465 hasAuthorship W2044228465A5033666255 @default.
- W2044228465 hasAuthorship W2044228465A5062359081 @default.
- W2044228465 hasAuthorship W2044228465A5075612136 @default.
- W2044228465 hasAuthorship W2044228465A5090080497 @default.
- W2044228465 hasBestOaLocation W20442284652 @default.
- W2044228465 hasConcept C121608353 @default.
- W2044228465 hasConcept C142724271 @default.
- W2044228465 hasConcept C150903083 @default.
- W2044228465 hasConcept C176999471 @default.
- W2044228465 hasConcept C189165786 @default.
- W2044228465 hasConcept C202751555 @default.
- W2044228465 hasConcept C207001950 @default.
- W2044228465 hasConcept C2778050619 @default.
- W2044228465 hasConcept C2778271429 @default.
- W2044228465 hasConcept C2779013556 @default.
- W2044228465 hasConcept C2779256057 @default.
- W2044228465 hasConcept C2779944901 @default.
- W2044228465 hasConcept C2780394083 @default.