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- W2044233695 abstract "Abstract The responses of the mammalian intestine to nervously released and externally applied ACh was tested when either true cholinesterase (acetylcholinesterase) or pseudocholinesterase activity was inhibited. Nicotine was used to cause ACh release from nerve endings while ACh added to the bath represented ACh of non-nervous origin. The specific cholinesterase inhibitors used were BW 284C51 for true cholinesterase inhibition and iso OMPA for pseudocholinesterase inhibition. When true cholinesterase was inhibited in the rat, rabbit or guinea-pig, the responses to both nervously released ACh and ACh of non-nervous origin were potentiated; the former (nicotine responses) being much more increased than the latter. Pseudo-cholinesterase inhibition in the rat or guinea-pig potentiated responses to externally applied ACh only. However, the rabbit differed in that the action of both nervously released and added ACh were potentiated after pseudocholinesterase inhibition. Control experiments were done to eliminate possible direct effects of the inhibitors on the sensitivity of the preparation. It is concluded that true cholinesterase normally functions in the removal of both nervous and non-nervous ACh, while pseudocholinesterase, in the rat and guinea-pig, destroys only ACh of non-nervous origin." @default.
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- W2044233695 date "1963-07-01" @default.
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- W2044233695 title "The function of true and pseudocholinesterase in the mammalian ileum" @default.
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- W2044233695 doi "https://doi.org/10.1016/0006-2952(63)90045-5" @default.
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