FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044238889> ?p ?o ?g. }

• W2044238889 endingPage "353" @default.
• W2044238889 startingPage "345" @default.
• W2044238889 abstract "A predominantly neurological presentation is common in patients with glutaric acidemia type I (GA-I). 3-hydroxyglutaric acid (3-OHGA), which accumulates in affected patients, has recently been demonstrated to play a central role in the neuropathogenesis of this disease. In the present study, we investigated the in vitro effects of 3-OHGA at concentrations ranging from 10 to 1000 microM on various parameters of the glutamatergic system, such as the basal and potassium-induced release of [3H]glutamate by synaptosomes, as well as on Na+-dependent [3H]glutamate uptake by synaptosomes and astrocytes and Na+-independent [3H]glutamate uptake by synaptic vesicles from cerebral cortex of 30-day-old Wistar rats. First, we observed that exposure of cultured astrocytes to 3-OHGA for 20 h did not reduce their viability. Furthermore, 3-OHGA significantly increased Na+-dependent [3H]glutamate uptake by astrocytes by up to 80% in a dose-dependent manner at doses as low as 30 microM. This effect was not dependent on the presence of the metabolite during the uptake assay, since it occurred even when 3-OHGA was withdrawn from the medium after cultured cells had been exposed to the acid for approximately 1 h. All other parameters investigated were not influenced by this organic acid, indicating a selective action of 3-OHGA on astrocyte transporters. Although the exact mechanisms involved in 3-OHGA-stimulatory effect on astrocyte glutamate uptake are unknown, the present findings contribute to the understanding of the pathophysiology of GA-I, suggesting that astrocytes may protect neurons against excitotoxic damage caused by 3-OHGA by increasing glutamate uptake and therefore reducing the concentration of this excitatory neurotransmitter in the synaptic cleft." @default.
• W2044238889 created "2016-06-24" @default.
• W2044238889 creator A5012579358 @default.
• W2044238889 creator A5026628044 @default.
• W2044238889 creator A5042250833 @default.
• W2044238889 creator A5047957337 @default.
• W2044238889 creator A5065558593 @default.
• W2044238889 creator A5068903875 @default.
• W2044238889 creator A5086724940 @default.
• W2044238889 creator A5088021168 @default.
• W2044238889 date "2004-04-01" @default.
• W2044238889 modified "2023-10-18" @default.
• W2044238889 title "3-Hydroxyglutaric acid enhances glutamate uptake into astrocytes from cerebral cortex of young rats" @default.
• W2044238889 cites W1491108164 @default.
• W2044238889 cites W1506990787 @default.
• W2044238889 cites W1597223461 @default.
• W2044238889 cites W1607257685 @default.
• W2044238889 cites W1629378997 @default.
• W2044238889 cites W1775749144 @default.
• W2044238889 cites W1965577864 @default.
• W2044238889 cites W1970306774 @default.
• W2044238889 cites W1976289522 @default.
• W2044238889 cites W1978025103 @default.
• W2044238889 cites W1982116658 @default.
• W2044238889 cites W1982807202 @default.
• W2044238889 cites W1985231669 @default.
• W2044238889 cites W1988467687 @default.
• W2044238889 cites W1989727987 @default.
• W2044238889 cites W1991220482 @default.
• W2044238889 cites W1996003758 @default.
• W2044238889 cites W2002668908 @default.
• W2044238889 cites W2003930457 @default.
• W2044238889 cites W2005725623 @default.
• W2044238889 cites W2008189718 @default.
• W2044238889 cites W2014856221 @default.
• W2044238889 cites W2019793131 @default.
• W2044238889 cites W2023811880 @default.
• W2044238889 cites W2025979409 @default.
• W2044238889 cites W2030024951 @default.
• W2044238889 cites W2042503380 @default.
• W2044238889 cites W2049382869 @default.
• W2044238889 cites W2058948754 @default.
• W2044238889 cites W2061244674 @default.
• W2044238889 cites W2061367597 @default.
• W2044238889 cites W2069012658 @default.
• W2044238889 cites W2069631533 @default.
• W2044238889 cites W2075274292 @default.
• W2044238889 cites W2076536920 @default.
• W2044238889 cites W2079905807 @default.
• W2044238889 cites W2082450845 @default.
• W2044238889 cites W2083461694 @default.
• W2044238889 cites W2086731122 @default.
• W2044238889 cites W2103926307 @default.
• W2044238889 cites W2116447221 @default.
• W2044238889 cites W2133505184 @default.
• W2044238889 cites W2138733394 @default.
• W2044238889 cites W2144529762 @default.
• W2044238889 cites W215415418 @default.
• W2044238889 cites W2154643237 @default.
• W2044238889 cites W2402265099 @default.
• W2044238889 cites W2403978899 @default.
• W2044238889 cites W2429572096 @default.
• W2044238889 cites W251431863 @default.
• W2044238889 cites W4210979710 @default.
• W2044238889 cites W4255689070 @default.
• W2044238889 doi "https://doi.org/10.1016/s0197-0186(03)00169-4" @default.
• W2044238889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14643752" @default.
• W2044238889 hasPublicationYear "2004" @default.
• W2044238889 type Work @default.
• W2044238889 sameAs 2044238889 @default.
• W2044238889 citedByCount "26" @default.
• W2044238889 countsByYear W20442388892013 @default.
• W2044238889 countsByYear W20442388892014 @default.
• W2044238889 countsByYear W20442388892016 @default.
• W2044238889 countsByYear W20442388892017 @default.
• W2044238889 countsByYear W20442388892021 @default.
• W2044238889 crossrefType "journal-article" @default.
• W2044238889 hasAuthorship W2044238889A5012579358 @default.
• W2044238889 hasAuthorship W2044238889A5026628044 @default.
• W2044238889 hasAuthorship W2044238889A5042250833 @default.
• W2044238889 hasAuthorship W2044238889A5047957337 @default.
• W2044238889 hasAuthorship W2044238889A5065558593 @default.
• W2044238889 hasAuthorship W2044238889A5068903875 @default.
• W2044238889 hasAuthorship W2044238889A5086724940 @default.
• W2044238889 hasAuthorship W2044238889A5088021168 @default.
• W2044238889 hasConcept C126322002 @default.
• W2044238889 hasConcept C134018914 @default.
• W2044238889 hasConcept C170493617 @default.
• W2044238889 hasConcept C185592680 @default.
• W2044238889 hasConcept C2776219046 @default.
• W2044238889 hasConcept C2777542381 @default.
• W2044238889 hasConcept C2778740566 @default.
• W2044238889 hasConcept C2780648746 @default.
• W2044238889 hasConcept C2780884517 @default.
• W2044238889 hasConcept C2781041448 @default.
• W2044238889 hasConcept C515207424 @default.
• W2044238889 hasConcept C529278444 @default.
• W2044238889 hasConcept C55493867 @default.

• next