FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044241187> ?p ?o ?g. }

• W2044241187 endingPage "1235" @default.
• W2044241187 startingPage "1223" @default.
• W2044241187 abstract "One percent of circulating IgG in humans recognizes galactose alpha 1,3 galactose residues (anti-Gal) and is synthesized in response to stimulation by enteric bacteria. In this study, we found that the prevalence of binding of anti-Gal to blood isolates is significantly higher than its binding to normal stool isolates. When anti-Gal bound onto the lipopolysaccharide of a representative blood isolate, Serratia marcescens #21, it blocked its alternative complement pathway (ACP) lysis and made the organism serum resistant. In contrast, when anti-Gal bound to the capsular polysaccharide of a serum sensitive Serratia, #7, it increased ACP killing of this strain. The mechanism of blockade of ACP lysis by anti-Gal did not involve a decrease in the number of C3 molecules deposited onto Serratia #21 or an inhibition of the binding of C3b to its LPS, nor did it change the iC3b and C3d degradation products of bound C3b or prevent membrane attack complex formation on this organism. Our findings suggest that the effect of anti-Gal on immune lysis is dependent on the bacterial outer membrane structure to which it binds. We postulate that anti-Gal may play a role in the survival of selected Enterobacteriacae in Gram-negative sepsis by blocking ACP-mediated lysis of such bacteria by the nonimmune host, and that this effect depends on where anti-Gal finds its epitope on the bacterial outer membrane." @default.
• W2044241187 created "2016-06-24" @default.
• W2044241187 creator A5000040521 @default.
• W2044241187 creator A5003801887 @default.
• W2044241187 creator A5014166659 @default.
• W2044241187 creator A5015010568 @default.
• W2044241187 creator A5065030286 @default.
• W2044241187 creator A5071451603 @default.
• W2044241187 date "1992-04-01" @default.
• W2044241187 modified "2023-10-16" @default.
• W2044241187 title "Human natural anti-Gal IgG regulates alternative complement pathway activation on bacterial surfaces." @default.
• W2044241187 cites W1502671196 @default.
• W2044241187 cites W1527717346 @default.
• W2044241187 cites W1530608250 @default.
• W2044241187 cites W1546439114 @default.
• W2044241187 cites W1557707473 @default.
• W2044241187 cites W1572857058 @default.
• W2044241187 cites W1574266659 @default.
• W2044241187 cites W1608773321 @default.
• W2044241187 cites W1618744733 @default.
• W2044241187 cites W1779768799 @default.
• W2044241187 cites W1885106571 @default.
• W2044241187 cites W1889024977 @default.
• W2044241187 cites W1922098314 @default.
• W2044241187 cites W1934547580 @default.
• W2044241187 cites W1939736255 @default.
• W2044241187 cites W1971264244 @default.
• W2044241187 cites W1977837863 @default.
• W2044241187 cites W2005329712 @default.
• W2044241187 cites W2012113843 @default.
• W2044241187 cites W2015242725 @default.
• W2044241187 cites W2015919943 @default.
• W2044241187 cites W2018289835 @default.
• W2044241187 cites W2029425292 @default.
• W2044241187 cites W2037634686 @default.
• W2044241187 cites W2043711606 @default.
• W2044241187 cites W2055392678 @default.
• W2044241187 cites W2062819575 @default.
• W2044241187 cites W2076722485 @default.
• W2044241187 cites W2078854426 @default.
• W2044241187 cites W2083418120 @default.
• W2044241187 cites W2100837269 @default.
• W2044241187 cites W2105876918 @default.
• W2044241187 cites W2111817213 @default.
• W2044241187 cites W2120968838 @default.
• W2044241187 cites W2121635085 @default.
• W2044241187 cites W2121996637 @default.
• W2044241187 cites W2122656843 @default.
• W2044241187 cites W2148591507 @default.
• W2044241187 cites W2149713514 @default.
• W2044241187 cites W2151591864 @default.
• W2044241187 cites W2164480655 @default.
• W2044241187 cites W2171648069 @default.
• W2044241187 cites W2171720113 @default.
• W2044241187 cites W45096837 @default.
• W2044241187 cites W54530014 @default.
• W2044241187 doi "https://doi.org/10.1172/jci115706" @default.
• W2044241187 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/442982" @default.
• W2044241187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1556184" @default.
• W2044241187 hasPublicationYear "1992" @default.
• W2044241187 type Work @default.
• W2044241187 sameAs 2044241187 @default.
• W2044241187 citedByCount "118" @default.
• W2044241187 countsByYear W20442411872012 @default.
• W2044241187 countsByYear W20442411872013 @default.
• W2044241187 countsByYear W20442411872014 @default.
• W2044241187 countsByYear W20442411872015 @default.
• W2044241187 countsByYear W20442411872017 @default.
• W2044241187 countsByYear W20442411872018 @default.
• W2044241187 countsByYear W20442411872019 @default.
• W2044241187 countsByYear W20442411872020 @default.
• W2044241187 countsByYear W20442411872021 @default.
• W2044241187 countsByYear W20442411872022 @default.
• W2044241187 countsByYear W20442411872023 @default.
• W2044241187 crossrefType "journal-article" @default.
• W2044241187 hasAuthorship W2044241187A5000040521 @default.
• W2044241187 hasAuthorship W2044241187A5003801887 @default.
• W2044241187 hasAuthorship W2044241187A5014166659 @default.
• W2044241187 hasAuthorship W2044241187A5015010568 @default.
• W2044241187 hasAuthorship W2044241187A5065030286 @default.
• W2044241187 hasAuthorship W2044241187A5071451603 @default.
• W2044241187 hasBestOaLocation W20442411871 @default.
• W2044241187 hasConcept C104317684 @default.
• W2044241187 hasConcept C111684460 @default.
• W2044241187 hasConcept C146587185 @default.
• W2044241187 hasConcept C159654299 @default.
• W2044241187 hasConcept C171279029 @default.
• W2044241187 hasConcept C185592680 @default.
• W2044241187 hasConcept C189446657 @default.
• W2044241187 hasConcept C191590540 @default.
• W2044241187 hasConcept C195616568 @default.
• W2044241187 hasConcept C203014093 @default.
• W2044241187 hasConcept C2776051709 @default.
• W2044241187 hasConcept C2776309202 @default.
• W2044241187 hasConcept C2776450100 @default.
• W2044241187 hasConcept C2778173381 @default.
• W2044241187 hasConcept C2778754761 @default.
• W2044241187 hasConcept C2781463711 @default.

• next