Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044244920> ?p ?o ?g. }
- W2044244920 endingPage "134" @default.
- W2044244920 startingPage "126" @default.
- W2044244920 abstract "There is evidence for migrational disturbances in the entorhinal cortex (ERC) in schizophrenia that supports a neurodevelopmental origin of the disorder. Since impaired myelin basic protein (MBP) gene expression during the migration phase could lead to abnormalities in final laminar position, we performed layer specific measurements of MBP expression in the ERC and hypothesised that migrational disturbances of pre-alpha-cell clusters relate to decreased MBP expression. Paraffin embedded sections of the left entorhinal cortex of 16 schizophrenia patients and 10 control subjects were stained for MBP using routine immunohistochemistry. On each section representative regions of interest were scanned to attain optimal quality images of the gray matter. Results were correlated to previous published disturbed dispersion of pre-alpha-cell clusters in adjacent brain sections. Mean MBP stain-intensity was significantly reduced in schizophrenia patients. Absolute MBP stain-intensity was significantly reduced in layers III and IV in patients. A significant correlation of MBP stain-intensity with the distance of the deep pole of the pre-alpha-cell cluster from the gray-white matter junction was observed in the ERC of schizophrenia patients. The present data provide evidence for reduced MBP expression in the ERC in schizophrenia, which implies deficits in axonal myelination and disturbed connectivity. MBP gene is expressed in oligodendrocytes and neuronal populations during embryonic development, which are important in establishing the structure of the cerebral cortex. Correlation between reduced MBP as a sign of down-regulated MBP gene expression and disorganization of pre-alpha-cell clusters supports a neurodevelopmental origin of pathological processes in schizophrenia." @default.
- W2044244920 created "2016-06-24" @default.
- W2044244920 creator A5011457700 @default.
- W2044244920 creator A5019181135 @default.
- W2044244920 creator A5025747179 @default.
- W2044244920 creator A5026246414 @default.
- W2044244920 creator A5031402912 @default.
- W2044244920 creator A5033183852 @default.
- W2044244920 creator A5042546910 @default.
- W2044244920 creator A5045648872 @default.
- W2044244920 creator A5054861340 @default.
- W2044244920 creator A5057664335 @default.
- W2044244920 creator A5058530050 @default.
- W2044244920 date "2009-11-01" @default.
- W2044244920 modified "2023-09-26" @default.
- W2044244920 title "Association between myelin basic protein expression and left entorhinal cortex pre-alpha cell layer disorganization in schizophrenia" @default.
- W2044244920 cites W132008894 @default.
- W2044244920 cites W1526861311 @default.
- W2044244920 cites W1964827701 @default.
- W2044244920 cites W1967979754 @default.
- W2044244920 cites W1969804821 @default.
- W2044244920 cites W1973350263 @default.
- W2044244920 cites W1980582117 @default.
- W2044244920 cites W1981719311 @default.
- W2044244920 cites W1987002276 @default.
- W2044244920 cites W1996717052 @default.
- W2044244920 cites W2001486260 @default.
- W2044244920 cites W2001888569 @default.
- W2044244920 cites W2003476788 @default.
- W2044244920 cites W2003960093 @default.
- W2044244920 cites W2005899067 @default.
- W2044244920 cites W2008268257 @default.
- W2044244920 cites W2020024506 @default.
- W2044244920 cites W2029084216 @default.
- W2044244920 cites W2029437594 @default.
- W2044244920 cites W2036691108 @default.
- W2044244920 cites W2039706207 @default.
- W2044244920 cites W2041713747 @default.
- W2044244920 cites W2041899662 @default.
- W2044244920 cites W2049973822 @default.
- W2044244920 cites W2052679154 @default.
- W2044244920 cites W2052842784 @default.
- W2044244920 cites W2055352726 @default.
- W2044244920 cites W2057565196 @default.
- W2044244920 cites W2058120616 @default.
- W2044244920 cites W2062803999 @default.
- W2044244920 cites W2062942165 @default.
- W2044244920 cites W2065094079 @default.
- W2044244920 cites W2067266085 @default.
- W2044244920 cites W2067646093 @default.
- W2044244920 cites W2071090720 @default.
- W2044244920 cites W2071697059 @default.
- W2044244920 cites W2072859446 @default.
- W2044244920 cites W2073953257 @default.
- W2044244920 cites W2074994762 @default.
- W2044244920 cites W2086061811 @default.
- W2044244920 cites W2088376011 @default.
- W2044244920 cites W2088454704 @default.
- W2044244920 cites W2105097410 @default.
- W2044244920 cites W2112572641 @default.
- W2044244920 cites W2119039616 @default.
- W2044244920 cites W2131577940 @default.
- W2044244920 cites W2133518122 @default.
- W2044244920 cites W2141202598 @default.
- W2044244920 cites W2144963822 @default.
- W2044244920 cites W2149845828 @default.
- W2044244920 cites W2151582451 @default.
- W2044244920 cites W2151814085 @default.
- W2044244920 cites W2158329357 @default.
- W2044244920 cites W2158363412 @default.
- W2044244920 cites W2160040915 @default.
- W2044244920 cites W2161900528 @default.
- W2044244920 cites W2167452733 @default.
- W2044244920 cites W2233634715 @default.
- W2044244920 cites W2400688595 @default.
- W2044244920 cites W2412732036 @default.
- W2044244920 cites W2761787180 @default.
- W2044244920 doi "https://doi.org/10.1016/j.brainres.2009.09.007" @default.
- W2044244920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19747901" @default.
- W2044244920 hasPublicationYear "2009" @default.
- W2044244920 type Work @default.
- W2044244920 sameAs 2044244920 @default.
- W2044244920 citedByCount "30" @default.
- W2044244920 countsByYear W20442449202012 @default.
- W2044244920 countsByYear W20442449202013 @default.
- W2044244920 countsByYear W20442449202014 @default.
- W2044244920 countsByYear W20442449202015 @default.
- W2044244920 countsByYear W20442449202016 @default.
- W2044244920 countsByYear W20442449202017 @default.
- W2044244920 countsByYear W20442449202018 @default.
- W2044244920 countsByYear W20442449202019 @default.
- W2044244920 countsByYear W20442449202020 @default.
- W2044244920 countsByYear W20442449202021 @default.
- W2044244920 countsByYear W20442449202022 @default.
- W2044244920 countsByYear W20442449202023 @default.
- W2044244920 crossrefType "journal-article" @default.
- W2044244920 hasAuthorship W2044244920A5011457700 @default.
- W2044244920 hasAuthorship W2044244920A5019181135 @default.