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- W2044255679 abstract "The syntheses and preliminary biological evaluation of conjugates of a synthetic isocyanurate-based trihydroxamate siderophore with two antifungal agents, 5-FU (conjugate 9) and norneoenactin (conjugate 12), and a macrolide antibiotic, erythromycylamine (conjugate 18), are described. A 19F NMR study was used to determine the hydrolytic stability of conjugate 9 under assay conditions. Preliminary biological studies with ferric complexes of conjugates 9 and 12 indicated that these antifungal agents are recognized by Candida and perhaps are actively transported into the cell by the siderophore-transport mechanisms. While conjugate 18 did not show any significant antibacterial activity, presumably due to size restriction, the 5-FU conjugate 9 appeared to be moderately active against a variety of Gram-positive strains, and was more active than the 5-FC control against some strains of Staphylococcus." @default.
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- W2044255679 date "1995-11-01" @default.
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- W2044255679 title "Design, synthesis, and biological evaluation of isocyanurate-based antifungal and macrolide antibiotic conjugates: Iron transport-mediated drug delivery" @default.
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- W2044255679 doi "https://doi.org/10.1016/0968-0896(95)00134-3" @default.
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