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- W2044268110 endingPage "101" @default.
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- W2044268110 abstract "Amide backbone and sidechain mutagenesis data can be used in combination with kinetic and thermodynamic measurements to understand the energetic contributions of backbone hydrogen bonding and the hydrophobic effect to the acquisition of β-sheet structure. For example, it has been revealed that loop 1 of the WW domain forms in the transition state, consistent with the emerging theme that reverse turn formation is rate limiting in β-sheet folding. A distinct subset of WW domain residues principally influences thermodynamic stability by forming hydrogen bonds and hydrophobic interactions that stabilize the native state. Energetic data and sequence mining reveal that only a small subset of the molecular information contained in sequences or observed in high-resolution structures is required to generate folded functional β-sheets, consistent with evolutionary robustness." @default.
- W2044268110 created "2016-06-24" @default.
- W2044268110 creator A5009810193 @default.
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- W2044268110 creator A5081499831 @default.
- W2044268110 creator A5091110455 @default.
- W2044268110 date "2006-02-01" @default.
- W2044268110 modified "2023-09-24" @default.
- W2044268110 title "β-Sheet folding mechanisms from perturbation energetics" @default.
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- W2044268110 doi "https://doi.org/10.1016/j.sbi.2006.01.014" @default.
- W2044268110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16442278" @default.
- W2044268110 hasPublicationYear "2006" @default.
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