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- W2044268886 abstract "Morphine was administered intracerebroventricularly to normal or recombinant inbred CXBK (μ-opioid receptor deficient) mice and antinociception was determined against two different stimuli. Morphine-induced antinociception agains acetylcholine was strain-dependent, whereas against endothelin-1 it was not. The antinociception was mediated via opioid μ receptors (blocked by β-FNA, but not naltrindole, ICI 174,864 or nor-BNI) through separate pathways, one naloxonazine-sensitive and the other naloxonazine-insensitive. Taken together, these results appear to demonstrate supraspinal morphine-induced antinociception through distinct subtypes of the μ opioid receptor, supporting the possibility of novel subtype-selective therepeutic agents with greater separation between analgesia and side-effects or physical dependence. Furthermore, the methodology described herein provides model systems for the in vivo screening of such agents." @default.
- W2044268886 created "2016-06-24" @default.
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- W2044268886 date "1994-01-01" @default.
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- W2044268886 title "Opioid μ receptor subtypes (possibly μ1 and μ2) revealed by morphine-induced antinociception vs endothelin-1 in recombinant inbred CXBK mice" @default.
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- W2044268886 doi "https://doi.org/10.1016/0024-3205(94)00822-1" @default.
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