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- W2044271663 abstract "To shorten the delay between coronary occlusion and thrombolytic treatment, we initiated a prehospital thrombolysis program, working in close cooperation with our local general practitioners and ambulance service. We found that thrombolytic treatment could be instituted 63 minutes earlier than in hospital. Furthermore, 28% of patients in the prehospital group were treated within 1 hour of symptom onset, a speed not matched by any patient in the hospital group. After 2 hours, these percentages became 65% and 25%, respectively. 1 Hooghoudt T.E.H Lamfers E.J.P Uppelschoten A Verheugt F.W.A Study of time intervals in myocardial ischemic syndromes (STIMIS). Cardiologie. 1998; 5: 23-30 Google Scholar Although a lower mortality rate is expected in patients who are treated earlier, this has been difficult to prove statistically with randomized trials. 2 Theroux P Coronary thrombolysis prehospital use. Can J Cardiol. 1993; 6: 521-522 Google Scholar Patients with an extensive acute myocardial infarction and thus a high mortality tend to seek help earlier, are easily diagnosed because of decisive electrocardiographic changes, and are thus favorable candidates for very early (prehospital) thrombolysis. A high mortality rate is thus found in the very early treated group, part of which would never have survived long enough for in-hospital thrombolysis. Indeed, the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO) trial confirms a higher mortality in patients who are treated very early. 3 GUSTO Angiopgraphic InvestigatorsThe effect of tissue plasminogen activator, streptokinase or both on coronary-artery patency, ventricular function, and survival after acute myocardial infarction. N Engl J Med. 1993; 329: 1515-1522 Google Scholar We therefore evaluated our prehospital thrombolysis program by comparing the number of aborted myocardial infarcts against those of patients treated in a nearby hospital without such a prehospital program." @default.
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- W2044271663 date "1999-10-01" @default.
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- W2044271663 title "Effect of prehospital thrombolysis on aborting acute myocardial infarction" @default.
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- W2044271663 doi "https://doi.org/10.1016/s0002-9149(99)00468-3" @default.
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