Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044273300> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2044273300 endingPage "492" @default.
- W2044273300 startingPage "485" @default.
- W2044273300 abstract "Gating current (Ig) underlying Na-channel activation is large enough to enable resolution of components both preceding and paralleling Na conductance (gNa) turn-on. For large depolarizations (beyond +20 mV), an additional slow phase of Ig is observed during a time when Na activation is already complete, but when K-channel opening is just becoming detectable. If Na- and K-channel gating are similar, the slow kinetics and long delay for K activation predict that K channel Ig must be relatively small and slow. Externally applied dibucaine almost totally blocks gNa and greatly reduces the fast (Na channel) Ig without altering gK or the Ig slow phase. The slow phase of Ig depends in part of the presence of functional K channels. Selective diminution in amplitude of the slow phase is consistently observed after a 30-min perfusion with both external and internal K-free media, a procedure which destroys nearly all K channels. This decrease of Ig amounts to approximately 10% of the total charge movements at +40 to +80 mV, with gating charge and K channels disappearing in a ratio of less than 1 e- per picosiemens of gK. These findings are consistent with the idea that part of the Ig slow phase represents gating current generated by the early steps in K-channel activation." @default.
- W2044273300 created "2016-06-24" @default.
- W2044273300 creator A5069282218 @default.
- W2044273300 creator A5071610785 @default.
- W2044273300 date "1980-03-01" @default.
- W2044273300 modified "2023-10-17" @default.
- W2044273300 title "Gating current and potassium channels in the giant axon of the squid" @default.
- W2044273300 cites W1589255772 @default.
- W2044273300 cites W1990323937 @default.
- W2044273300 cites W2016448112 @default.
- W2044273300 cites W2042710603 @default.
- W2044273300 cites W2087135536 @default.
- W2044273300 cites W2100282855 @default.
- W2044273300 cites W2119786838 @default.
- W2044273300 cites W2126725618 @default.
- W2044273300 cites W2129227107 @default.
- W2044273300 cites W4253271002 @default.
- W2044273300 doi "https://doi.org/10.1016/s0006-3495(80)85147-2" @default.
- W2044273300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1328681" @default.
- W2044273300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6271271" @default.
- W2044273300 hasPublicationYear "1980" @default.
- W2044273300 type Work @default.
- W2044273300 sameAs 2044273300 @default.
- W2044273300 citedByCount "39" @default.
- W2044273300 countsByYear W20442733002012 @default.
- W2044273300 countsByYear W20442733002016 @default.
- W2044273300 countsByYear W20442733002018 @default.
- W2044273300 countsByYear W20442733002019 @default.
- W2044273300 crossrefType "journal-article" @default.
- W2044273300 hasAuthorship W2044273300A5069282218 @default.
- W2044273300 hasAuthorship W2044273300A5071610785 @default.
- W2044273300 hasBestOaLocation W20442733001 @default.
- W2044273300 hasConcept C121332964 @default.
- W2044273300 hasConcept C121932024 @default.
- W2044273300 hasConcept C12554922 @default.
- W2044273300 hasConcept C178790620 @default.
- W2044273300 hasConcept C185592680 @default.
- W2044273300 hasConcept C194544171 @default.
- W2044273300 hasConcept C26873012 @default.
- W2044273300 hasConcept C44280652 @default.
- W2044273300 hasConcept C50952357 @default.
- W2044273300 hasConcept C537181965 @default.
- W2044273300 hasConcept C83743174 @default.
- W2044273300 hasConcept C86803240 @default.
- W2044273300 hasConceptScore W2044273300C121332964 @default.
- W2044273300 hasConceptScore W2044273300C121932024 @default.
- W2044273300 hasConceptScore W2044273300C12554922 @default.
- W2044273300 hasConceptScore W2044273300C178790620 @default.
- W2044273300 hasConceptScore W2044273300C185592680 @default.
- W2044273300 hasConceptScore W2044273300C194544171 @default.
- W2044273300 hasConceptScore W2044273300C26873012 @default.
- W2044273300 hasConceptScore W2044273300C44280652 @default.
- W2044273300 hasConceptScore W2044273300C50952357 @default.
- W2044273300 hasConceptScore W2044273300C537181965 @default.
- W2044273300 hasConceptScore W2044273300C83743174 @default.
- W2044273300 hasConceptScore W2044273300C86803240 @default.
- W2044273300 hasIssue "3" @default.
- W2044273300 hasLocation W20442733001 @default.
- W2044273300 hasLocation W20442733002 @default.
- W2044273300 hasLocation W20442733003 @default.
- W2044273300 hasLocation W20442733004 @default.
- W2044273300 hasOpenAccess W2044273300 @default.
- W2044273300 hasPrimaryLocation W20442733001 @default.
- W2044273300 hasRelatedWork W1636088266 @default.
- W2044273300 hasRelatedWork W1969238396 @default.
- W2044273300 hasRelatedWork W2002540382 @default.
- W2044273300 hasRelatedWork W2031449089 @default.
- W2044273300 hasRelatedWork W2112596406 @default.
- W2044273300 hasRelatedWork W2125499229 @default.
- W2044273300 hasRelatedWork W4385304246 @default.
- W2044273300 hasRelatedWork W4387096018 @default.
- W2044273300 hasRelatedWork W4387096070 @default.
- W2044273300 hasRelatedWork W4387096269 @default.
- W2044273300 hasVolume "29" @default.
- W2044273300 isParatext "false" @default.
- W2044273300 isRetracted "false" @default.
- W2044273300 magId "2044273300" @default.
- W2044273300 workType "article" @default.