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• W2044273571 endingPage "1145" @default.
• W2044273571 startingPage "1134" @default.
• W2044273571 abstract "Cell plasma membranes contain a variety of transport systems that carry acid or base into or out of the cell. Research over the past decade has led to remarkable advances in our understanding of these acid-base transport systems and has established that they have several major physiological roles. They are the primary means by which cells regulate their internal pH and they also contribute importantly to regulation of cell volume and possibly cell proliferation. Furthermore, in the gastrointestinal tract they mediate absorption and secretion, not only of acids and bases but of several other electrolytes and nutrients. The major acid-base transport systems on mammalian cell plasma membranes are illustrated in Figures 1-3; their specific locations on different cell types are discussed later. Hydrogen, potassium (H+,K+) adenosine triphosphatase (ATPase) extrude H+ in exchange for K' using energy derived directly from ATP hydrolysis. They are present on the apical membranes of gastric parietal cells' (Fig 1) and, in some species, colon epithelial cells,2 where they mediate acid secretion. However, they are not widely distributed in gastrointestinal epithelia. Other acid base transport systems derive their energy, not directly from ATP hydrolysis, but from coupling the movement of one ion to passive movement of another ion along its electrochemical gradient. In the case of sodium/ hydrogen (Na+/H+) exchange (Figs 1-3), H' extrusion from the cell is coupled, in a 1: 1 ratio, to Na+ entry down its chemical gradient.3-' This gradient depends on the sodium pump, Na+,K+ ATPase, which is present on the basolateral membrane of all gastrointestinal epithelial cells and extrudes 3 Na+ ions in exchange for 2 K+ ions, thus maintaining a low intracellular [Na+], high intracellular [K'], and negative intracellular potential. Na+/H+ exchange is almost ubiquitous in mammalian cells and can be inhibited by the diuretic amiloride. There are several mechanisms for bicarbonate (HCO3 ) transport across plasma membranes.67 In most tissues, the enzyme carbonic anhydrase mediates rapid equilibration of H' and HCO3 with C02, which diffuses freely across all cell membranes. Therefore, HCO3 transport into the cell is equivalent to H` transport out of the cell and vice versa. In the case of chloride/bicarbonate (Cl-/ HC03 ) exchange (Figs 1-3), HCO3 extrusion from the cell is coupled, in a 1:1 ratio, to Cl entry along its chemical gradient. This gradirnt H+ HCO33Na+" @default.
• W2044273571 created "2016-06-24" @default.
• W2044273571 creator A5066456072 @default.
• W2044273571 date "1992-08-01" @default.
• W2044273571 modified "2023-10-15" @default.
• W2044273571 title "Acid-base transport systems in gastrointestinal epithelia." @default.
• W2044273571 cites W101807314 @default.
• W2044273571 cites W113601383 @default.
• W2044273571 cites W142299042 @default.
• W2044273571 cites W1480345605 @default.
• W2044273571 cites W1483011130 @default.
• W2044273571 cites W1494199361 @default.
• W2044273571 cites W1495349070 @default.
• W2044273571 cites W1501954533 @default.
• W2044273571 cites W1506334396 @default.
• W2044273571 cites W1506819190 @default.
• W2044273571 cites W1522902096 @default.
• W2044273571 cites W1532880215 @default.
• W2044273571 cites W1535881345 @default.
• W2044273571 cites W1536062608 @default.
• W2044273571 cites W1542845577 @default.
• W2044273571 cites W1552354790 @default.
• W2044273571 cites W1558100345 @default.
• W2044273571 cites W1567364863 @default.
• W2044273571 cites W1578508637 @default.
• W2044273571 cites W1580672895 @default.
• W2044273571 cites W1602958737 @default.
• W2044273571 cites W1655637944 @default.
• W2044273571 cites W1659460275 @default.
• W2044273571 cites W1704469833 @default.
• W2044273571 cites W1709493989 @default.
• W2044273571 cites W1732737686 @default.
• W2044273571 cites W1784542440 @default.
• W2044273571 cites W1798074647 @default.
• W2044273571 cites W1802242543 @default.
• W2044273571 cites W1835526604 @default.
• W2044273571 cites W1891220346 @default.
• W2044273571 cites W189305868 @default.
• W2044273571 cites W1902730133 @default.
• W2044273571 cites W1942690484 @default.
• W2044273571 cites W1965180344 @default.
• W2044273571 cites W1967989557 @default.
• W2044273571 cites W1972196375 @default.
• W2044273571 cites W1976517937 @default.
• W2044273571 cites W1977235189 @default.
• W2044273571 cites W1978610957 @default.
• W2044273571 cites W1979496441 @default.
• W2044273571 cites W1979618407 @default.
• W2044273571 cites W1981553330 @default.
• W2044273571 cites W1982683257 @default.
• W2044273571 cites W1982972448 @default.
• W2044273571 cites W1983768617 @default.
• W2044273571 cites W1986481940 @default.
• W2044273571 cites W1990862848 @default.
• W2044273571 cites W1991737476 @default.
• W2044273571 cites W1994796965 @default.
• W2044273571 cites W1998390329 @default.
• W2044273571 cites W1999662264 @default.
• W2044273571 cites W2000734999 @default.
• W2044273571 cites W2003003393 @default.
• W2044273571 cites W2005441073 @default.
• W2044273571 cites W2011748538 @default.
• W2044273571 cites W2011987388 @default.
• W2044273571 cites W2014882842 @default.
• W2044273571 cites W2016608550 @default.
• W2044273571 cites W2018473499 @default.
• W2044273571 cites W2022972067 @default.
• W2044273571 cites W2023222044 @default.
• W2044273571 cites W2024188093 @default.
• W2044273571 cites W2025100148 @default.
• W2044273571 cites W2026255173 @default.
• W2044273571 cites W2026949273 @default.
• W2044273571 cites W2027092642 @default.
• W2044273571 cites W2031835500 @default.
• W2044273571 cites W2039796275 @default.
• W2044273571 cites W2040841039 @default.
• W2044273571 cites W2045494796 @default.
• W2044273571 cites W2049605074 @default.
• W2044273571 cites W2053142040 @default.
• W2044273571 cites W2057474701 @default.
• W2044273571 cites W2057595921 @default.
• W2044273571 cites W2058687449 @default.
• W2044273571 cites W2060508967 @default.
• W2044273571 cites W2062418026 @default.
• W2044273571 cites W2066362211 @default.
• W2044273571 cites W2067013864 @default.
• W2044273571 cites W2067158279 @default.
• W2044273571 cites W2068747742 @default.
• W2044273571 cites W2077830910 @default.
• W2044273571 cites W2082887846 @default.
• W2044273571 cites W2085420048 @default.
• W2044273571 cites W2085985515 @default.
• W2044273571 cites W2087299454 @default.
• W2044273571 cites W2088205844 @default.
• W2044273571 cites W2091319839 @default.
• W2044273571 cites W2098576078 @default.
• W2044273571 cites W2103353757 @default.
• W2044273571 cites W2106002281 @default.

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