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- W2044279473 abstract "Macrophages are innate immune cells derived from monocytes, which, in turn, arise from myeloid precursor cells in the bone marrow. Macrophages have many important roles in the innate and adaptive immune response, as well as in tissue homeostasis. Two major populations have been defined: The classically activated macrophages that respond to intracellular pathogens by secreting proinflammatory cytokines and reactive oxygen species and alternatively activated macrophages which are induced during Th2 responses displaying anti-inflammatory activities. Both macrophage populations are central players in diabetes, the first one triggering inflammatory responses which initiates insulitis and pancreatic<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>cell death during type 1 diabetes, whereas the second population decreases hyperglycemia, insulitis, and inflammation in the pancreas, thereby negatively regulate type 1 diabetes. Obesity is an important factor in the development of type 2 diabetes; classically activated macrophages are a dominant cell population involved in the establishment of the inflammatory profile, insulin resistance, and activation of inflammatory signals during the development and progression of this disease. In contrast, alternatively activated macrophages regulate the release of proinflammatory cytokines, attenuating adipose tissue inflammation. Here, we review the advantages and disadvantages of these two macrophage populations with regard to their roles in types 1 and 2 diabetes." @default.
- W2044279473 created "2016-06-24" @default.
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- W2044279473 date "2012-01-01" @default.
- W2044279473 modified "2023-10-16" @default.
- W2044279473 title "Alternatively Activated Macrophages in Types 1 and 2 Diabetes" @default.
- W2044279473 cites W1530509485 @default.
- W2044279473 cites W1621676818 @default.
- W2044279473 cites W1653545152 @default.
- W2044279473 cites W1734802175 @default.
- W2044279473 cites W1764140709 @default.
- W2044279473 cites W1873730442 @default.
- W2044279473 cites W1966241241 @default.
- W2044279473 cites W1966599724 @default.
- W2044279473 cites W1969616767 @default.
- W2044279473 cites W1970398616 @default.
- W2044279473 cites W1975580739 @default.
- W2044279473 cites W1977267646 @default.
- W2044279473 cites W1983783590 @default.
- W2044279473 cites W1983831001 @default.
- W2044279473 cites W1986109976 @default.
- W2044279473 cites W1988128973 @default.
- W2044279473 cites W1991401793 @default.
- W2044279473 cites W1995962823 @default.
- W2044279473 cites W1996904143 @default.
- W2044279473 cites W2003084688 @default.
- W2044279473 cites W2003571862 @default.
- W2044279473 cites W2004345178 @default.
- W2044279473 cites W2004679090 @default.
- W2044279473 cites W2016451329 @default.
- W2044279473 cites W2020060493 @default.
- W2044279473 cites W2020267609 @default.
- W2044279473 cites W2022645718 @default.
- W2044279473 cites W2027604252 @default.
- W2044279473 cites W2031874852 @default.
- W2044279473 cites W2033946555 @default.
- W2044279473 cites W2035141288 @default.
- W2044279473 cites W2036176663 @default.
- W2044279473 cites W2037798159 @default.
- W2044279473 cites W2038689279 @default.
- W2044279473 cites W2039175393 @default.
- W2044279473 cites W2039434363 @default.
- W2044279473 cites W2042750241 @default.
- W2044279473 cites W2042854425 @default.
- W2044279473 cites W2050441306 @default.
- W2044279473 cites W2051686027 @default.
- W2044279473 cites W2058857909 @default.
- W2044279473 cites W2065210647 @default.
- W2044279473 cites W2069474631 @default.
- W2044279473 cites W2069746141 @default.
- W2044279473 cites W2075349184 @default.
- W2044279473 cites W2094669111 @default.
- W2044279473 cites W2096429786 @default.
- W2044279473 cites W2101331467 @default.
- W2044279473 cites W2102473693 @default.
- W2044279473 cites W2102541996 @default.
- W2044279473 cites W2105212262 @default.
- W2044279473 cites W2107020458 @default.
- W2044279473 cites W2110188726 @default.
- W2044279473 cites W2113491191 @default.
- W2044279473 cites W2114528797 @default.
- W2044279473 cites W2115907216 @default.
- W2044279473 cites W2116424088 @default.
- W2044279473 cites W2118382770 @default.
- W2044279473 cites W2120563506 @default.
- W2044279473 cites W2123950558 @default.
- W2044279473 cites W2127379971 @default.
- W2044279473 cites W2127559758 @default.
- W2044279473 cites W2128627731 @default.
- W2044279473 cites W2130064617 @default.
- W2044279473 cites W2130569466 @default.
- W2044279473 cites W2132099317 @default.
- W2044279473 cites W2132595586 @default.
- W2044279473 cites W2138134702 @default.
- W2044279473 cites W2140472119 @default.
- W2044279473 cites W2145697808 @default.
- W2044279473 cites W2146561547 @default.
- W2044279473 cites W2147326548 @default.
- W2044279473 cites W2149589945 @default.
- W2044279473 cites W2150210328 @default.
- W2044279473 cites W2152037832 @default.
- W2044279473 cites W2156280702 @default.
- W2044279473 cites W2159841585 @default.
- W2044279473 cites W2160247072 @default.
- W2044279473 cites W2165202791 @default.
- W2044279473 cites W2167485774 @default.
- W2044279473 cites W2171119405 @default.
- W2044279473 cites W4238497443 @default.
- W2044279473 cites W4249727000 @default.
- W2044279473 cites W4249919387 @default.
- W2044279473 doi "https://doi.org/10.1155/2012/815953" @default.
- W2044279473 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3543813" @default.
- W2044279473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23326021" @default.
- W2044279473 hasPublicationYear "2012" @default.
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