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- W2044279872 abstract "ABSTRACT Hepatitis C virus (HCV) leads to progressive liver disease and hepatocellular carcinoma. Current treatments are only partially effective, and new therapies targeting viral and host pathways are required. Virus entry into a host cell provides a conserved target for therapeutic intervention. Tetraspanin CD81, scavenger receptor class B member I, and the tight-junction proteins claudin-1 and occludin have been identified as essential entry receptors. Limited information is available on the role of receptor trafficking in HCV entry. We demonstrate here that anti-CD81 antibodies inhibit HCV infection at late times after virus internalization, suggesting a role for intracellular CD81 in HCV infection. Several tetraspanins have been reported to internalize via motifs in their C-terminal cytoplasmic domains; however, CD81 lacks such motifs, leading several laboratories to suggest a limited role for CD81 endocytosis in HCV entry. We demonstrate CD81 internalization via a clathrin- and dynamin-dependent process, independent of its cytoplasmic domain, suggesting a role for associated partner proteins in regulating CD81 trafficking. Live cell imaging demonstrates CD81 and claudin-1 coendocytosis and fusion with Rab5 expressing endosomes, supporting a role for this receptor complex in HCV internalization. Receptor-specific antibodies and HCV particles increase CD81 and claudin-1 endocytosis, supporting a model wherein HCV stimulates receptor trafficking to promote particle internalization." @default.
- W2044279872 created "2016-06-24" @default.
- W2044279872 creator A5000713711 @default.
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- W2044279872 date "2012-04-15" @default.
- W2044279872 modified "2023-10-18" @default.
- W2044279872 title "Hepatitis C Virus Induces CD81 and Claudin-1 Endocytosis" @default.
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- W2044279872 doi "https://doi.org/10.1128/jvi.06996-11" @default.
- W2044279872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3318669" @default.
- W2044279872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22318146" @default.
- W2044279872 hasPublicationYear "2012" @default.
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