Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044281505> ?p ?o ?g. }
- W2044281505 endingPage "240" @default.
- W2044281505 startingPage "235" @default.
- W2044281505 abstract "Tricin was evaluated as a type of tyrosinase inhibitor with good efficacy compared to arbutin. Tricin functioned as a non-competitive inhibitor of tyrosinase, with an equilibrium constant of 2.30 mmol/L. The molecular mechanisms underlying the inhibition of tyrosinase by tricin were investigated by means of circular dichroism spectra, fluorescence quenching and molecular docking. These assays demonstrated that the interactions between tricin and tyrosinase did not change the secondary structure. The interaction of tricin with residues in the hydrophobic pocket of tyrosinase was revealed by fluorescence quenching; the complex was stabilized by hydrophobic associations and hydrogen bonding (with residues Asn80 and Arg267). Docking results implied that the possible inhibitory mechanisms may be attributed to the stereospecific blockade effects of tricin on substrates or products and flexible conformation alterations in the tyrosinase active center caused by weak interactions between tyrosinase and tricin. The application of this type of flavonoid as a tyrosinase inhibitor will lead to significant advances in the field of depigmentation." @default.
- W2044281505 created "2016-06-24" @default.
- W2044281505 creator A5014369438 @default.
- W2044281505 creator A5023132497 @default.
- W2044281505 creator A5058965019 @default.
- W2044281505 date "2013-04-01" @default.
- W2044281505 modified "2023-10-07" @default.
- W2044281505 title "Molecular inhibitory mechanism of tricin on tyrosinase" @default.
- W2044281505 cites W1577286320 @default.
- W2044281505 cites W1967817108 @default.
- W2044281505 cites W1968931762 @default.
- W2044281505 cites W1969819436 @default.
- W2044281505 cites W1971218701 @default.
- W2044281505 cites W1972768037 @default.
- W2044281505 cites W1973387903 @default.
- W2044281505 cites W1975305359 @default.
- W2044281505 cites W1975629953 @default.
- W2044281505 cites W1975966519 @default.
- W2044281505 cites W1981735274 @default.
- W2044281505 cites W1982022971 @default.
- W2044281505 cites W1984681622 @default.
- W2044281505 cites W1984923138 @default.
- W2044281505 cites W1993729889 @default.
- W2044281505 cites W1995725157 @default.
- W2044281505 cites W2001409168 @default.
- W2044281505 cites W2011805570 @default.
- W2044281505 cites W2012915823 @default.
- W2044281505 cites W2016205318 @default.
- W2044281505 cites W2024156915 @default.
- W2044281505 cites W2052230935 @default.
- W2044281505 cites W2052257620 @default.
- W2044281505 cites W2071055678 @default.
- W2044281505 cites W2075705506 @default.
- W2044281505 cites W2077711961 @default.
- W2044281505 cites W2103591844 @default.
- W2044281505 cites W2103994532 @default.
- W2044281505 cites W2156931352 @default.
- W2044281505 cites W2158113006 @default.
- W2044281505 cites W2313912827 @default.
- W2044281505 cites W2315649409 @default.
- W2044281505 cites W2322431142 @default.
- W2044281505 cites W2352454854 @default.
- W2044281505 doi "https://doi.org/10.1016/j.saa.2013.01.058" @default.
- W2044281505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23434549" @default.
- W2044281505 hasPublicationYear "2013" @default.
- W2044281505 type Work @default.
- W2044281505 sameAs 2044281505 @default.
- W2044281505 citedByCount "39" @default.
- W2044281505 countsByYear W20442815052013 @default.
- W2044281505 countsByYear W20442815052014 @default.
- W2044281505 countsByYear W20442815052015 @default.
- W2044281505 countsByYear W20442815052016 @default.
- W2044281505 countsByYear W20442815052017 @default.
- W2044281505 countsByYear W20442815052018 @default.
- W2044281505 countsByYear W20442815052019 @default.
- W2044281505 countsByYear W20442815052020 @default.
- W2044281505 countsByYear W20442815052021 @default.
- W2044281505 countsByYear W20442815052022 @default.
- W2044281505 countsByYear W20442815052023 @default.
- W2044281505 crossrefType "journal-article" @default.
- W2044281505 hasAuthorship W2044281505A5014369438 @default.
- W2044281505 hasAuthorship W2044281505A5023132497 @default.
- W2044281505 hasAuthorship W2044281505A5058965019 @default.
- W2044281505 hasConcept C112887158 @default.
- W2044281505 hasConcept C159110408 @default.
- W2044281505 hasConcept C178790620 @default.
- W2044281505 hasConcept C181199279 @default.
- W2044281505 hasConcept C185592680 @default.
- W2044281505 hasConcept C2778004101 @default.
- W2044281505 hasConcept C2779054382 @default.
- W2044281505 hasConcept C2779545570 @default.
- W2044281505 hasConcept C2781424683 @default.
- W2044281505 hasConcept C32909587 @default.
- W2044281505 hasConcept C41685203 @default.
- W2044281505 hasConcept C55493867 @default.
- W2044281505 hasConcept C71240020 @default.
- W2044281505 hasConcept C71924100 @default.
- W2044281505 hasConcept C87554066 @default.
- W2044281505 hasConceptScore W2044281505C112887158 @default.
- W2044281505 hasConceptScore W2044281505C159110408 @default.
- W2044281505 hasConceptScore W2044281505C178790620 @default.
- W2044281505 hasConceptScore W2044281505C181199279 @default.
- W2044281505 hasConceptScore W2044281505C185592680 @default.
- W2044281505 hasConceptScore W2044281505C2778004101 @default.
- W2044281505 hasConceptScore W2044281505C2779054382 @default.
- W2044281505 hasConceptScore W2044281505C2779545570 @default.
- W2044281505 hasConceptScore W2044281505C2781424683 @default.
- W2044281505 hasConceptScore W2044281505C32909587 @default.
- W2044281505 hasConceptScore W2044281505C41685203 @default.
- W2044281505 hasConceptScore W2044281505C55493867 @default.
- W2044281505 hasConceptScore W2044281505C71240020 @default.
- W2044281505 hasConceptScore W2044281505C71924100 @default.
- W2044281505 hasConceptScore W2044281505C87554066 @default.
- W2044281505 hasLocation W20442815051 @default.
- W2044281505 hasLocation W20442815052 @default.
- W2044281505 hasOpenAccess W2044281505 @default.
- W2044281505 hasPrimaryLocation W20442815051 @default.
- W2044281505 hasRelatedWork W2017223650 @default.