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- W2044282983 abstract "Abstract Objective To examine the role that insulin signaling plays in modulating metabolic functions involving both peripheral and hypothalamic systems. Methods We review the literature regarding insulin signaling as it relates to energy homeostasis. Results Insulin signaling in the periphery is known to affect hepatic glucose production and glucose uptake in muscle and adipose tissue. In the brain, insulin is involved in a variety of signaling pathways that control positive and negative aspects of food intake and energy metabolism. Disruption of insulin signaling can affect key cellular pathways that serve to maintain energy balance and glucose homeostasis, which can then lead to insulin resistance and progression toward various metabolic disorders, including cardiovascular disease, obesity, and type 2 diabetes. The use of exogenous insulin as therapy for patients with type 2 diabetes is traditionally associated with increases in weight. Conclusion An enhanced understanding of how these insulin signaling pathways function may provide answers about how to control weight gain associated with exogenous insulin use. Pharmacologic agents, such as the long-acting insulin analogues and particularly insulin detemir, that may reduce these weight effects hold considerable advantage. (Endocr Pract. 2008;14:373-380)" @default.
- W2044282983 created "2016-06-24" @default.
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- W2044282983 date "2008-04-01" @default.
- W2044282983 modified "2023-09-25" @default.
- W2044282983 title "Role of Insulin Signaling in Maintaining Energy Homeostasis" @default.
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- W2044282983 doi "https://doi.org/10.4158/ep.14.3.373" @default.
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