FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044283388> ?p ?o ?g. }

• W2044283388 endingPage "407" @default.
• W2044283388 startingPage "400" @default.
• W2044283388 abstract "Psacalium peltatum (H.B.K.) Cass. (Asteraceae) is used medicinally to treat diabetes, rheumatic pains, as well as gastrointestinal and kidney ailments. Previous pharmacological and chemical assays have demonstrated that an aqueous fraction from Psacalium peltatum (AP-fraction) contains a carbohydrate-type compound with hypoglycemic activity. Nevertheless, studies have not yet considered the hypoglycemic action of the AP-faction by sub-chronic administration nor on other healing properties, some of which might be associated with DM2 and other inflammatory processes. To determine whether a hypoglycemic carbohydrate fraction (AP-fraction) from Psacalium peltatum roots has antioxidant and anti-inflammatory effects in streptozotocin-induced diabetes mice. Healthy mice received either saline, the AP-fraction with a high content of fructans, or pioglitazone (a positive control) daily by gavage. After 15 days of treatment, these animals received a single intraperitoneal administration of streptozotocin and all treatments were continued for additional 33 days. The antioxidant and anti-inflammatory properties of the AP-fraction were evaluated through the quantification of biomarkers of oxidative stress (glutathione (GSH) and malondialdehyde (MDA)) and inflammation (interleukin (IL)-6, tumor necrosis factor alpha (TNF-α), interferon-gamma (IFN-γ), and IL-10). The AP-fraction reduced glycemia and the glycated hemoglobin. Furthermore, animals treated with the AP-fraction had increased GSH, while MDA was decreased in the liver and the heart, without changes in the kidneys and the pancreas. The AP-fraction significantly reduced TNF-α serum levels but did not modify IL-6; in addition, this fraction increased IFN-γ and IL-10 levels. The increase in IL-10 levels may indicate an inhibition of the production of pro-inflammatory cytokines such as TNF-α, whereas the increase in IFN-γ might be indicative of a beneficial effect on the immune system. The AP-fraction hypoglycemic fructans from Psacalium peltatum roots showed antioxidant and anti-inflammatory properties in mice with streptozotocin-induced diabetes. The Psacalium peltatum hypoglycemic fructans may be valuable in preventing insulin resistance, as well as the development and progression of diabetic complications caused by chronic inflammation." @default.
• W2044283388 created "2016-06-24" @default.
• W2044283388 creator A5003293800 @default.
• W2044283388 creator A5015562454 @default.
• W2044283388 creator A5037631807 @default.
• W2044283388 creator A5041385092 @default.
• W2044283388 creator A5043229372 @default.
• W2044283388 creator A5055994447 @default.
• W2044283388 creator A5064790847 @default.
• W2044283388 creator A5071954858 @default.
• W2044283388 creator A5081333307 @default.
• W2044283388 creator A5087109959 @default.
• W2044283388 date "2010-11-01" @default.
• W2044283388 modified "2023-10-18" @default.
• W2044283388 title "Anti-inflammatory and antioxidant effects of a hypoglycemic fructan fraction from Psacalium peltatum (H.B.K.) Cass. in streptozotocin-induced diabetes mice" @default.
• W2044283388 cites W1480466711 @default.
• W2044283388 cites W1538399032 @default.
• W2044283388 cites W1560649513 @default.
• W2044283388 cites W1870696988 @default.
• W2044283388 cites W1983821154 @default.
• W2044283388 cites W1986093496 @default.
• W2044283388 cites W1994289453 @default.
• W2044283388 cites W2013195172 @default.
• W2044283388 cites W2015897746 @default.
• W2044283388 cites W2036705116 @default.
• W2044283388 cites W2044437167 @default.
• W2044283388 cites W2048563316 @default.
• W2044283388 cites W2051784121 @default.
• W2044283388 cites W2060669742 @default.
• W2044283388 cites W2062522909 @default.
• W2044283388 cites W2063576996 @default.
• W2044283388 cites W2065906579 @default.
• W2044283388 cites W2066407086 @default.
• W2044283388 cites W2069396466 @default.
• W2044283388 cites W2076884949 @default.
• W2044283388 cites W2080999576 @default.
• W2044283388 cites W2097065632 @default.
• W2044283388 cites W2097815597 @default.
• W2044283388 cites W2104135200 @default.
• W2044283388 cites W2115556861 @default.
• W2044283388 cites W2122242241 @default.
• W2044283388 cites W2123560318 @default.
• W2044283388 cites W2127191881 @default.
• W2044283388 cites W2139079059 @default.
• W2044283388 cites W2140793658 @default.
• W2044283388 cites W2149142370 @default.
• W2044283388 cites W2151022783 @default.
• W2044283388 cites W2161477191 @default.
• W2044283388 cites W2170839629 @default.
• W2044283388 cites W2469307620 @default.
• W2044283388 cites W2980508099 @default.
• W2044283388 cites W4231718623 @default.
• W2044283388 cites W4245957869 @default.
• W2044283388 doi "https://doi.org/10.1016/j.jep.2010.08.003" @default.
• W2044283388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20713141" @default.
• W2044283388 hasPublicationYear "2010" @default.
• W2044283388 type Work @default.
• W2044283388 sameAs 2044283388 @default.
• W2044283388 citedByCount "19" @default.
• W2044283388 countsByYear W20442833882012 @default.
• W2044283388 countsByYear W20442833882013 @default.
• W2044283388 countsByYear W20442833882014 @default.
• W2044283388 countsByYear W20442833882016 @default.
• W2044283388 countsByYear W20442833882017 @default.
• W2044283388 countsByYear W20442833882018 @default.
• W2044283388 countsByYear W20442833882020 @default.
• W2044283388 countsByYear W20442833882021 @default.
• W2044283388 crossrefType "journal-article" @default.
• W2044283388 hasAuthorship W2044283388A5003293800 @default.
• W2044283388 hasAuthorship W2044283388A5015562454 @default.
• W2044283388 hasAuthorship W2044283388A5037631807 @default.
• W2044283388 hasAuthorship W2044283388A5041385092 @default.
• W2044283388 hasAuthorship W2044283388A5043229372 @default.
• W2044283388 hasAuthorship W2044283388A5055994447 @default.
• W2044283388 hasAuthorship W2044283388A5064790847 @default.
• W2044283388 hasAuthorship W2044283388A5071954858 @default.
• W2044283388 hasAuthorship W2044283388A5081333307 @default.
• W2044283388 hasAuthorship W2044283388A5087109959 @default.
• W2044283388 hasConcept C126322002 @default.
• W2044283388 hasConcept C134018914 @default.
• W2044283388 hasConcept C181199279 @default.
• W2044283388 hasConcept C185592680 @default.
• W2044283388 hasConcept C2776151105 @default.
• W2044283388 hasConcept C2777180221 @default.
• W2044283388 hasConcept C2777538456 @default.
• W2044283388 hasConcept C2778004101 @default.
• W2044283388 hasConcept C2779280383 @default.
• W2044283388 hasConcept C538909803 @default.
• W2044283388 hasConcept C55493867 @default.
• W2044283388 hasConcept C555293320 @default.
• W2044283388 hasConcept C71924100 @default.
• W2044283388 hasConcept C98274493 @default.
• W2044283388 hasConceptScore W2044283388C126322002 @default.
• W2044283388 hasConceptScore W2044283388C134018914 @default.
• W2044283388 hasConceptScore W2044283388C181199279 @default.
• W2044283388 hasConceptScore W2044283388C185592680 @default.
• W2044283388 hasConceptScore W2044283388C2776151105 @default.
• W2044283388 hasConceptScore W2044283388C2777180221 @default.

• next