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• W2044285871 startingPage "49" @default.
• W2044285871 abstract "RNA silencing phenomena were first discovered in plants, yet only the RNA interference pathway in animals has been subject to biochemical analysis. Here, we extend biochemical analysis to plant RNA silencing. We find that standard wheat germ extract contains Dicer-like enzymes that convert double-stranded RNA (dsRNA) into two classes of small interfering RNAs, as well as an RNA-dependent RNA polymerase activity that can convert exogenous single-stranded RNA into dsRNA. In this plant embryo extract, an endogenous microRNA (miRNA) that lacks perfect complementarity to its RNA targets nonetheless acts as a small interfering RNA. The miRNA guides an endonuclease to cleave efficiently wild-type Arabidopsis PHAVOLUTA mRNA, but not a dominant mutant previously shown to perturb leaf development. This finding supports the view that plant miRNAs direct RNAi and that miRNA-specified mRNA destruction is important for proper plant development. Thus, endonuclease complexes guided by small RNAs are a common feature of RNA silencing in both animals and plants." @default.
• W2044285871 created "2016-06-24" @default.
• W2044285871 creator A5020225652 @default.
• W2044285871 creator A5059910089 @default.
• W2044285871 creator A5083906598 @default.
• W2044285871 creator A5087589263 @default.
• W2044285871 date "2003-01-01" @default.
• W2044285871 modified "2023-10-11" @default.
• W2044285871 title "A biochemical framework for RNA silencing in plants" @default.
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• W2044285871 doi "https://doi.org/10.1101/gad.1048103" @default.
• W2044285871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/195971" @default.
• W2044285871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12514099" @default.
• W2044285871 hasPublicationYear "2003" @default.
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