Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044286212> ?p ?o ?g. }
- W2044286212 endingPage "76" @default.
- W2044286212 startingPage "71" @default.
- W2044286212 abstract "Folate deficiency induces neurotoxicity by multiple routes, including increasing cytosolic calcium and oxidative stress via increasing levels of the neurotoxin homocysteine (HC), and inducing mitochondrial and DNA damage. Because some of these neurotoxic effects overlap with those observed in motor neuron disease, we examined the impact of folate deprivation on dorsal root ganglion (DRG) neurons in culture. Folate deprivation for 2 h increased cytosolic calcium and reactive oxygen species (ROS) and impaired mitochondrial function. Treatment with nimodipine [an L voltage-sensitive calcium channel (LVSCC) antagonist], MK-801 (an NMDA channel antagonist) and thapsigarin (an inhibitor of efflux of calcium from internal stores) indicated that folate deprivation initially induced calcium influx via the LVSCC, with subsequent additional calcium derived from NMDA channels and internal stores. These compounds also reduced ROS and mitochondrial degeneration, indicating that calcium influx contributed to these phenomena. Calcium influx was prevented by co-treatment with 3-deaza-adenosine, which inhibits HC formation, indicating that HC mediated increased cytosolic calcium following folate deprivation. Nimodipine, MK-801 and thapsigargin had similar effects following direct treatment with HC as they did following folate deprivation. These findings support the idea that folate deprivation and HC treatment can compromise the health of DRG neurons by perturbing calcium homeostasis." @default.
- W2044286212 created "2016-06-24" @default.
- W2044286212 creator A5022729293 @default.
- W2044286212 creator A5024573960 @default.
- W2044286212 creator A5054444756 @default.
- W2044286212 creator A5059634441 @default.
- W2044286212 creator A5067695200 @default.
- W2044286212 creator A5076207530 @default.
- W2044286212 date "2004-03-22" @default.
- W2044286212 modified "2023-10-15" @default.
- W2044286212 title "Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation" @default.
- W2044286212 cites W152764626 @default.
- W2044286212 cites W1533350566 @default.
- W2044286212 cites W1672668838 @default.
- W2044286212 cites W1938194578 @default.
- W2044286212 cites W1945836171 @default.
- W2044286212 cites W1950408523 @default.
- W2044286212 cites W1963687683 @default.
- W2044286212 cites W1969698644 @default.
- W2044286212 cites W1980608195 @default.
- W2044286212 cites W1986682670 @default.
- W2044286212 cites W1990439966 @default.
- W2044286212 cites W1994876221 @default.
- W2044286212 cites W2000298063 @default.
- W2044286212 cites W2001305840 @default.
- W2044286212 cites W2009138784 @default.
- W2044286212 cites W2014217419 @default.
- W2044286212 cites W2015372700 @default.
- W2044286212 cites W2043448850 @default.
- W2044286212 cites W2046298613 @default.
- W2044286212 cites W2047248785 @default.
- W2044286212 cites W2051118048 @default.
- W2044286212 cites W2052211882 @default.
- W2044286212 cites W2072768138 @default.
- W2044286212 cites W2072815626 @default.
- W2044286212 cites W2073260254 @default.
- W2044286212 cites W2074354890 @default.
- W2044286212 cites W2081375684 @default.
- W2044286212 cites W2081737897 @default.
- W2044286212 cites W2084461848 @default.
- W2044286212 cites W2085527691 @default.
- W2044286212 cites W2087443548 @default.
- W2044286212 cites W2105135681 @default.
- W2044286212 cites W2110588833 @default.
- W2044286212 cites W2125501179 @default.
- W2044286212 cites W2126230337 @default.
- W2044286212 cites W2145901639 @default.
- W2044286212 cites W2149336243 @default.
- W2044286212 cites W2168103097 @default.
- W2044286212 cites W2170125790 @default.
- W2044286212 cites W4213096683 @default.
- W2044286212 cites W89480579 @default.
- W2044286212 doi "https://doi.org/10.1111/j.1474-9728.2004.00086.x" @default.
- W2044286212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15038821" @default.
- W2044286212 hasPublicationYear "2004" @default.
- W2044286212 type Work @default.
- W2044286212 sameAs 2044286212 @default.
- W2044286212 citedByCount "62" @default.
- W2044286212 countsByYear W20442862122012 @default.
- W2044286212 countsByYear W20442862122013 @default.
- W2044286212 countsByYear W20442862122014 @default.
- W2044286212 countsByYear W20442862122015 @default.
- W2044286212 countsByYear W20442862122016 @default.
- W2044286212 countsByYear W20442862122017 @default.
- W2044286212 countsByYear W20442862122018 @default.
- W2044286212 countsByYear W20442862122019 @default.
- W2044286212 countsByYear W20442862122020 @default.
- W2044286212 countsByYear W20442862122021 @default.
- W2044286212 countsByYear W20442862122022 @default.
- W2044286212 countsByYear W20442862122023 @default.
- W2044286212 crossrefType "journal-article" @default.
- W2044286212 hasAuthorship W2044286212A5022729293 @default.
- W2044286212 hasAuthorship W2044286212A5024573960 @default.
- W2044286212 hasAuthorship W2044286212A5054444756 @default.
- W2044286212 hasAuthorship W2044286212A5059634441 @default.
- W2044286212 hasAuthorship W2044286212A5067695200 @default.
- W2044286212 hasAuthorship W2044286212A5076207530 @default.
- W2044286212 hasBestOaLocation W20442862121 @default.
- W2044286212 hasConcept C105702510 @default.
- W2044286212 hasConcept C126322002 @default.
- W2044286212 hasConcept C134018914 @default.
- W2044286212 hasConcept C140530291 @default.
- W2044286212 hasConcept C170493617 @default.
- W2044286212 hasConcept C18699975 @default.
- W2044286212 hasConcept C2776281502 @default.
- W2044286212 hasConcept C2777294900 @default.
- W2044286212 hasConcept C2779491297 @default.
- W2044286212 hasConcept C29730261 @default.
- W2044286212 hasConcept C30979828 @default.
- W2044286212 hasConcept C519063684 @default.
- W2044286212 hasConcept C55493867 @default.
- W2044286212 hasConcept C67018056 @default.
- W2044286212 hasConcept C71924100 @default.
- W2044286212 hasConcept C86803240 @default.
- W2044286212 hasConceptScore W2044286212C105702510 @default.
- W2044286212 hasConceptScore W2044286212C126322002 @default.
- W2044286212 hasConceptScore W2044286212C134018914 @default.
- W2044286212 hasConceptScore W2044286212C140530291 @default.