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• W2044286906 startingPage "410" @default.
• W2044286906 abstract "Alterations of the phospholipid (PL) compositions of body fluids are assumed to be indicative of inflammatory diseases, e.g. rheumatoid arthritis (RA). Recently, we have shown that particularly the phosphatidylcholine/lysophosphatidylcholine (PC/LPC) ratio determined in human synovial fluids (SF) and sera represents a reliable measure of the inflammatory state in RA patients. However, it is not yet clear to what extent the PC/LPC ratio is also affected by nutrition habits. In the present study, the PL and the corresponding acyl chain compositions of human body fluids (SF and serum of RA patients as well as serum from healthy volunteers) are compared with those of two other mammalian species (horses and dogs suffering from degenerative joint diseases as well as healthy controls) by high-resolution 31P-nuclear magnetic resonance (NMR) spectroscopy and matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS). The most important result of this study is that the PL compositions of SF and serum of horse and dog are comparable with those of human body fluids. Compared with humans, however, the horse body fluid contains less PCs with highly unsaturated arachidonoyl residues, while that of dogs possesses the highest content of arachidonoyl-containing PC. These species-related differences stem primarily from different nutrition habits (meat vs. plants)." @default.
• W2044286906 created "2016-06-24" @default.
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• W2044286906 date "2009-07-08" @default.
• W2044286906 modified "2023-10-10" @default.
• W2044286906 title "Phospholipid compositions of sera and synovial fluids from dog, human and horse: a comparison by³¹P-NMR and MALDI-TOF MS" @default.
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• W2044286906 doi "https://doi.org/10.1111/j.1439-0396.2008.00822.x" @default.
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• W2044286906 hasPublicationYear "2009" @default.
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