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• W2044288521 abstract "Ghrelin is a growth hormone (GH) secretagogue (GHS) and GHRP-6 is a synthetic peptide analogue; both act through the GHS receptor. GH secretion depends directly on the intracellular concentration of Ca 2+ ; this is determined from the intracellular reserves and by the entrance of Ca 2+ through the voltage-dependent calcium channels, which are activated by the membrane depolarization. Membrane potential is mainly determined by K + channels. In the present work, we investigated the effect of ghrelin (10 nM) or GHRP-6 (100 nM) for 96 h on functional expression of voltage-dependent K + channels in rat somatotropes: GC cell line. Physiological patch-clamp whole-cell recording was used to register the K + currents. With Cd 2+ (1 mM) and tetrodotoxin (1 μ m) in the bath solution recording, three types of currents were characterized on the basis of their biophysical and pharmacological properties. GC cells showed a K + current with a transitory component sensitive to 4-aminopyridine, which represents ~40% of the total outgoing current; a sustained component named delayed rectifier , sensitive to tetraethylammonium; and a third type of K + current was recorded at potentials more negative than −80 mV, permitting the entrance of K + named inward rectifier (K IR ). Chronic treatment with ghrelin or GHRP-6 did not modify the functional expression of K + channels, without significant changes () in the amplitudes of the three currents observed; in addition, there were no modifications in their biophysical properties and kinetic activation or inactivation." @default.
• W2044288521 created "2016-06-24" @default.
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• W2044288521 date "2013-02-24" @default.
• W2044288521 modified "2023-10-06" @default.
• W2044288521 title "Potassium Current Is Not Affected by Long-Term Exposure to Ghrelin or GHRP-6 in Somatotropes GC Cells" @default.
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• W2044288521 doi "https://doi.org/10.1155/2013/913792" @default.
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