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• W2044289375 abstract "Novel 2,4-diaminoquinazoline derivatives originating from a virtual screening approach were designed, synthesized and their biological activities as heat shock protein 90 (Hsp90) inhibitors were evaluated. The prepared compounds exhibited significant anti-proliferative activities against DU-145, HT-29, HCT-116, A375P and MCF-7 cancer cell lines. The selected compounds were tested against Her2, a client protein of Hsp90, and showed significant reduction in Her2 protein expression. Compound 6b was found the most potent, reduced Her2 protein expression levels and induced Hsp70 protein expression levels significantly." @default.
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• W2044289375 date "2011-03-01" @default.
• W2044289375 modified "2023-09-27" @default.
• W2044289375 title "Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors" @default.
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• W2044289375 doi "https://doi.org/10.1016/j.bmcl.2011.01.117" @default.
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