FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044292045> ?p ?o ?g. }

• W2044292045 endingPage "380" @default.
• W2044292045 startingPage "367" @default.
• W2044292045 abstract "MacroH2A histones are variants of canonical histone H2A that are conserved among vertebrates. Previous studies have implicated macroH2As in epigenetic gene-silencing events including X chromosome inactivation. Here we show that macroH2A is present in developing and mature mouse oocytes. MacroH2A is localized to chromatin of germinal vesicles (GV) in both late growth stage (lg-GV) and fully grown (fg-GV) stage oocytes. In addition, macroH2A is associated with the chromosomes of mature oocytes, and abundant macroH2A is present in the first polar body. However, maternal macroH2A is lost from zygotes generated by normal fertilization by the late 2 pronuclei (2PN) stage. Normal embryos at 2-, 4-, and 8-cell stages lack macroH2A except in residual polar bodies. MacroH2A protein expression reappears in embryos after the 8-cell stage and persists in morulae and blastocysts, where nuclear macroH2A is present in both the trophectodermal and inner cell mass cells. We followed the loss of macroH2A from pronuclei in parthenogenetic embryos generated by oocyte activation. Abundant macroH2A is present upon the metaphase II plate and persists through parthenogenetic anaphase, but macroH2A is progressively lost during pronuclear decondensation prior to synkaryogamy. Examination of embryos generated by intracytoplasmic sperm injection (ICSI) revealed that macroH2A is associated exclusively with female pronuclei prior to loss in late pronucleus stage embryos. These results outline a surprising finding that a maternal store of macroH2A is removed from the maternal genome prior to synkaryogamy, resulting in embryos that execute three to four mitotic divisions in the absence of macroH2A prior to the onset of embryonic macroH2A expression." @default.
• W2044292045 created "2016-06-24" @default.
• W2044292045 creator A5011547811 @default.
• W2044292045 creator A5018953105 @default.
• W2044292045 creator A5068156605 @default.
• W2044292045 creator A5081300653 @default.
• W2044292045 creator A5081565390 @default.
• W2044292045 creator A5083121536 @default.
• W2044292045 date "2005-02-01" @default.
• W2044292045 modified "2023-09-24" @default.
• W2044292045 title "A maternal store of macroH2A is removed from pronuclei prior to onset of somatic macroH2A expression in preimplantation embryos" @default.
• W2044292045 cites W1522147759 @default.
• W2044292045 cites W1603793127 @default.
• W2044292045 cites W1880656333 @default.
• W2044292045 cites W1903601470 @default.
• W2044292045 cites W1971589767 @default.
• W2044292045 cites W1973727308 @default.
• W2044292045 cites W1974302507 @default.
• W2044292045 cites W1975849323 @default.
• W2044292045 cites W1981084918 @default.
• W2044292045 cites W1987477108 @default.
• W2044292045 cites W1988413102 @default.
• W2044292045 cites W1989841784 @default.
• W2044292045 cites W1990710362 @default.
• W2044292045 cites W1997053831 @default.
• W2044292045 cites W2004664852 @default.
• W2044292045 cites W2009580999 @default.
• W2044292045 cites W2013283920 @default.
• W2044292045 cites W2016546533 @default.
• W2044292045 cites W2025525406 @default.
• W2044292045 cites W2035574894 @default.
• W2044292045 cites W2037231961 @default.
• W2044292045 cites W2055322019 @default.
• W2044292045 cites W2068690942 @default.
• W2044292045 cites W2073545879 @default.
• W2044292045 cites W2074382192 @default.
• W2044292045 cites W2083308605 @default.
• W2044292045 cites W2089253191 @default.
• W2044292045 cites W2101177674 @default.
• W2044292045 cites W2108582115 @default.
• W2044292045 cites W2131278882 @default.
• W2044292045 cites W2140113078 @default.
• W2044292045 cites W2141452262 @default.
• W2044292045 cites W2147810289 @default.
• W2044292045 cites W2149690124 @default.
• W2044292045 cites W2156104195 @default.
• W2044292045 cites W2160839840 @default.
• W2044292045 cites W2167083524 @default.
• W2044292045 cites W2171767359 @default.
• W2044292045 cites W2270546804 @default.
• W2044292045 cites W369563225 @default.
• W2044292045 doi "https://doi.org/10.1016/j.ydbio.2004.11.032" @default.
• W2044292045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15680357" @default.
• W2044292045 hasPublicationYear "2005" @default.
• W2044292045 type Work @default.
• W2044292045 sameAs 2044292045 @default.
• W2044292045 citedByCount "71" @default.
• W2044292045 countsByYear W20442920452012 @default.
• W2044292045 countsByYear W20442920452013 @default.
• W2044292045 countsByYear W20442920452014 @default.
• W2044292045 countsByYear W20442920452015 @default.
• W2044292045 countsByYear W20442920452016 @default.
• W2044292045 countsByYear W20442920452017 @default.
• W2044292045 countsByYear W20442920452018 @default.
• W2044292045 countsByYear W20442920452019 @default.
• W2044292045 countsByYear W20442920452020 @default.
• W2044292045 countsByYear W20442920452021 @default.
• W2044292045 countsByYear W20442920452022 @default.
• W2044292045 crossrefType "journal-article" @default.
• W2044292045 hasAuthorship W2044292045A5011547811 @default.
• W2044292045 hasAuthorship W2044292045A5018953105 @default.
• W2044292045 hasAuthorship W2044292045A5068156605 @default.
• W2044292045 hasAuthorship W2044292045A5081300653 @default.
• W2044292045 hasAuthorship W2044292045A5081565390 @default.
• W2044292045 hasAuthorship W2044292045A5083121536 @default.
• W2044292045 hasConcept C110758877 @default.
• W2044292045 hasConcept C153911025 @default.
• W2044292045 hasConcept C16685009 @default.
• W2044292045 hasConcept C196843134 @default.
• W2044292045 hasConcept C2778177303 @default.
• W2044292045 hasConcept C28748434 @default.
• W2044292045 hasConcept C54355233 @default.
• W2044292045 hasConcept C71924100 @default.
• W2044292045 hasConcept C86803240 @default.
• W2044292045 hasConcept C87073359 @default.
• W2044292045 hasConceptScore W2044292045C110758877 @default.
• W2044292045 hasConceptScore W2044292045C153911025 @default.
• W2044292045 hasConceptScore W2044292045C16685009 @default.
• W2044292045 hasConceptScore W2044292045C196843134 @default.
• W2044292045 hasConceptScore W2044292045C2778177303 @default.
• W2044292045 hasConceptScore W2044292045C28748434 @default.
• W2044292045 hasConceptScore W2044292045C54355233 @default.
• W2044292045 hasConceptScore W2044292045C71924100 @default.
• W2044292045 hasConceptScore W2044292045C86803240 @default.
• W2044292045 hasConceptScore W2044292045C87073359 @default.
• W2044292045 hasIssue "2" @default.
• W2044292045 hasLocation W20442920451 @default.
• W2044292045 hasLocation W20442920452 @default.

• next