Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044293321> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2044293321 abstract "Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CAConstitutive activation of the B-Raf/MKK/ERK signaling pathway a result of B-Raf activating mutations is a hallmark of over two-thirds of melanomas. The most prevalent mutation, B-RafV600E, promotes cancer cell behavior through mechanisms which are still incompletely defined. We utilized microRNA (miRNA) microarray profiling to identify a network of more than 20 miRNAs deregulated by B-Raf/MKK/ERK in melanoma cells, the majority of which modulate expression of key cancer regulatory genes and functions. Importantly, miRNAs within the network converge on protein regulation and cancer phenotypes, suggesting that these miRNAs might function combinatorially. Additionally, by altering functional levels of these miRNAs in cells with miRNA mimics and inhibitors we demonstrate that miRNAs augment effects on protein repression and cell invasion when co-expressed, and we also observe gene-specific latency and interference effects between miRNAs. Thus, B-Raf/MKK/ERK controls key aspects of cancer cell behavior and gene expression by modulating a network of miRNAs with cross-regulatory functions. The findings highlight the potential for complex interactions between coordinately regulated miRNAs within a gene expression network.Citation Format: Kasey L. Couts, Emily M. Anderson, Maren M. Gross, Kevin Sullivan, Natalie G. Ahn. A network of microRNAs contolled by oncogenic B-Raf signaling in melanoma cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5245. doi:10.1158/1538-7445.AM2014-5245" @default.
- W2044293321 created "2016-06-24" @default.
- W2044293321 creator A5034522474 @default.
- W2044293321 creator A5051284682 @default.
- W2044293321 creator A5066949514 @default.
- W2044293321 creator A5078810034 @default.
- W2044293321 creator A5088690520 @default.
- W2044293321 date "2014-09-30" @default.
- W2044293321 modified "2023-09-27" @default.
- W2044293321 title "Abstract 5245: A network of microRNAs contolled by oncogenic B-Raf signaling in melanoma cells" @default.
- W2044293321 doi "https://doi.org/10.1158/1538-7445.am2014-5245" @default.
- W2044293321 hasPublicationYear "2014" @default.
- W2044293321 type Work @default.
- W2044293321 sameAs 2044293321 @default.
- W2044293321 citedByCount "0" @default.
- W2044293321 crossrefType "proceedings-article" @default.
- W2044293321 hasAuthorship W2044293321A5034522474 @default.
- W2044293321 hasAuthorship W2044293321A5051284682 @default.
- W2044293321 hasAuthorship W2044293321A5066949514 @default.
- W2044293321 hasAuthorship W2044293321A5078810034 @default.
- W2044293321 hasAuthorship W2044293321A5088690520 @default.
- W2044293321 hasConcept C104317684 @default.
- W2044293321 hasConcept C121608353 @default.
- W2044293321 hasConcept C145059251 @default.
- W2044293321 hasConcept C2777658100 @default.
- W2044293321 hasConcept C502942594 @default.
- W2044293321 hasConcept C54355233 @default.
- W2044293321 hasConcept C57074206 @default.
- W2044293321 hasConcept C62478195 @default.
- W2044293321 hasConcept C86803240 @default.
- W2044293321 hasConcept C96232424 @default.
- W2044293321 hasConceptScore W2044293321C104317684 @default.
- W2044293321 hasConceptScore W2044293321C121608353 @default.
- W2044293321 hasConceptScore W2044293321C145059251 @default.
- W2044293321 hasConceptScore W2044293321C2777658100 @default.
- W2044293321 hasConceptScore W2044293321C502942594 @default.
- W2044293321 hasConceptScore W2044293321C54355233 @default.
- W2044293321 hasConceptScore W2044293321C57074206 @default.
- W2044293321 hasConceptScore W2044293321C62478195 @default.
- W2044293321 hasConceptScore W2044293321C86803240 @default.
- W2044293321 hasConceptScore W2044293321C96232424 @default.
- W2044293321 hasLocation W20442933211 @default.
- W2044293321 hasOpenAccess W2044293321 @default.
- W2044293321 hasPrimaryLocation W20442933211 @default.
- W2044293321 hasRelatedWork W1506033400 @default.
- W2044293321 hasRelatedWork W1968002534 @default.
- W2044293321 hasRelatedWork W1979413046 @default.
- W2044293321 hasRelatedWork W2016301582 @default.
- W2044293321 hasRelatedWork W2048893832 @default.
- W2044293321 hasRelatedWork W2049770961 @default.
- W2044293321 hasRelatedWork W2096761002 @default.
- W2044293321 hasRelatedWork W2097352128 @default.
- W2044293321 hasRelatedWork W2120442434 @default.
- W2044293321 hasRelatedWork W2151993669 @default.
- W2044293321 hasRelatedWork W2163806026 @default.
- W2044293321 hasRelatedWork W2174882028 @default.
- W2044293321 hasRelatedWork W2313065565 @default.
- W2044293321 hasRelatedWork W2330627301 @default.
- W2044293321 hasRelatedWork W2331757584 @default.
- W2044293321 hasRelatedWork W2339636540 @default.
- W2044293321 hasRelatedWork W2357931808 @default.
- W2044293321 hasRelatedWork W2408763720 @default.
- W2044293321 hasRelatedWork W2414201962 @default.
- W2044293321 hasRelatedWork W2586064700 @default.
- W2044293321 isParatext "false" @default.
- W2044293321 isRetracted "false" @default.
- W2044293321 magId "2044293321" @default.
- W2044293321 workType "article" @default.