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- W204429377 abstract "This chapter discusses interactions of piperonyl butoxide (PBO) with cytochrome P450. Cytochrome P450s occur both as constitutive and inducible enzymes, and a number of foreign compounds are known to induce specific P450 isozymes. P450 substrates serve as inducing agents, inducing the isozymes active in their metabolism. Because of the importance of the P450 enzymes in metabolism and significant health-related consequences associated with inducing or repressing specific P450 isozymes, there is considerable interest in studying P450 regulation, the activities of specific isozymes, and the chemicals involved in the interactions with P450. PBO is a substrate, an inhibitor, and an inducer of P450 in mammals and in insects. PBO could function as a P450 inducer and because of the relatively fast rate of P450 inhibition in comparison with P450 induction, the time course of effects in mammals is biphasic. PBO is not only an effective insecticide synergist because of its interaction with P450, but owing to the same interaction, it is also useful as a diagnostic tool in pesticide toxicology in the determination of whether or not P450-dependent mono-oxygenation is involved in the metabolism of a particular pesticide and whether or not P450 mono-oxygenation is involved in resistance when resistant populations are discovered." @default.
- W204429377 created "2016-06-24" @default.
- W204429377 creator A5024035685 @default.
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- W204429377 date "1999-01-01" @default.
- W204429377 modified "2023-10-02" @default.
- W204429377 title "Interactions of Piperonyl Butoxide with Cytochrome P450" @default.
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- W204429377 doi "https://doi.org/10.1016/b978-012286975-4/50005-x" @default.
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