Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044302013> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2044302013 endingPage "421" @default.
- W2044302013 startingPage "419" @default.
- W2044302013 abstract "Pascal J. Goldschmidt-Clermont’ and Paul A. Janmeyt *Department of Medicine Cardiology Division The Johns Hopkins University School of Medicine Baltimore, Maryland 21205 tExperimental Medicine Division Brigham and Women’s Hospital Harvard Medical School Boston, Massachusetts 02115 Many cells such as platelets and fibroblasts change their shape and move in response to extracellular agonists. This is considered to be a crucial step, because it often occurs when cells become committed to the accomplishment of a function, growth, or even transformation. Much has been learned about the membrane events involved in cell signal- ing (Cantley et al., 1991). Concurrently, major discoveries have been made concerning the structure of the cytoskele- ton that controls cell shape and motility (Stossel, 1989; Pollard, 1990). The connection between membrane activ- ity and cytoskeletal structure has remained a mystery. However, specific interactions between proteins of the actin-based skeleton and key molecules of membrane sig- naling pathways have been identified in vitro and now in vivo: the actin-binding protein profilin may contribute to a signaling pathway in Saccharomyces cerevisiae that is regulated by RAS, the ubiquitous GTPase that plays a central role in differentiation, growth, and proliferation of diverse cells (Hall, 1990) and by the adenyl cyclase-asso- ciated protein known as CAP (Vojtek et al., 1991). In S. cerevisiae, the only cell in which an effector of RAS has been characterized, RAS activates adenylate cyclase. This effect specifically requires the N-terminal domain of CAP (Gerst et al., 1991; Figure 1). The phenotype of yeast cells that are null for CAP or its C-terminal domain resem- bles that of yeast cells depleted of profilin by gene disrup- tion. They grow slowly, become very large and round, and have budding and nutritional defects. In yeast cells null for" @default.
- W2044302013 created "2016-06-24" @default.
- W2044302013 creator A5028268542 @default.
- W2044302013 creator A5060576956 @default.
- W2044302013 date "1991-08-01" @default.
- W2044302013 modified "2023-09-23" @default.
- W2044302013 title "Profilin, a weak CAP for actin and RAS" @default.
- W2044302013 cites W1972617251 @default.
- W2044302013 cites W1990232581 @default.
- W2044302013 cites W2005529016 @default.
- W2044302013 cites W2009671832 @default.
- W2044302013 cites W2012709757 @default.
- W2044302013 cites W2017100096 @default.
- W2044302013 cites W2022129165 @default.
- W2044302013 cites W2050759207 @default.
- W2044302013 cites W2058009854 @default.
- W2044302013 cites W2073125687 @default.
- W2044302013 cites W2076300921 @default.
- W2044302013 cites W2078835916 @default.
- W2044302013 cites W2081809068 @default.
- W2044302013 cites W2085154580 @default.
- W2044302013 cites W2093741736 @default.
- W2044302013 cites W2102666800 @default.
- W2044302013 cites W2115158821 @default.
- W2044302013 cites W2135977869 @default.
- W2044302013 cites W2170766885 @default.
- W2044302013 cites W2415905438 @default.
- W2044302013 cites W4239924819 @default.
- W2044302013 doi "https://doi.org/10.1016/0092-8674(81)90002-7" @default.
- W2044302013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1651167" @default.
- W2044302013 hasPublicationYear "1991" @default.
- W2044302013 type Work @default.
- W2044302013 sameAs 2044302013 @default.
- W2044302013 citedByCount "89" @default.
- W2044302013 countsByYear W20443020132019 @default.
- W2044302013 crossrefType "journal-article" @default.
- W2044302013 hasAuthorship W2044302013A5028268542 @default.
- W2044302013 hasAuthorship W2044302013A5060576956 @default.
- W2044302013 hasBestOaLocation W20443020131 @default.
- W2044302013 hasConcept C125705527 @default.
- W2044302013 hasConcept C142669718 @default.
- W2044302013 hasConcept C1491633281 @default.
- W2044302013 hasConcept C203253989 @default.
- W2044302013 hasConcept C2993400109 @default.
- W2044302013 hasConcept C54355233 @default.
- W2044302013 hasConcept C86803240 @default.
- W2044302013 hasConcept C95444343 @default.
- W2044302013 hasConceptScore W2044302013C125705527 @default.
- W2044302013 hasConceptScore W2044302013C142669718 @default.
- W2044302013 hasConceptScore W2044302013C1491633281 @default.
- W2044302013 hasConceptScore W2044302013C203253989 @default.
- W2044302013 hasConceptScore W2044302013C2993400109 @default.
- W2044302013 hasConceptScore W2044302013C54355233 @default.
- W2044302013 hasConceptScore W2044302013C86803240 @default.
- W2044302013 hasConceptScore W2044302013C95444343 @default.
- W2044302013 hasIssue "3" @default.
- W2044302013 hasLocation W20443020131 @default.
- W2044302013 hasLocation W20443020132 @default.
- W2044302013 hasOpenAccess W2044302013 @default.
- W2044302013 hasPrimaryLocation W20443020131 @default.
- W2044302013 hasRelatedWork W1870009775 @default.
- W2044302013 hasRelatedWork W1970473512 @default.
- W2044302013 hasRelatedWork W1983813017 @default.
- W2044302013 hasRelatedWork W2023968719 @default.
- W2044302013 hasRelatedWork W2029422324 @default.
- W2044302013 hasRelatedWork W2100648267 @default.
- W2044302013 hasRelatedWork W2101173100 @default.
- W2044302013 hasRelatedWork W2167561185 @default.
- W2044302013 hasRelatedWork W2410457297 @default.
- W2044302013 hasRelatedWork W4281251820 @default.
- W2044302013 hasVolume "66" @default.
- W2044302013 isParatext "false" @default.
- W2044302013 isRetracted "false" @default.
- W2044302013 magId "2044302013" @default.
- W2044302013 workType "article" @default.