FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044303962> ?p ?o ?g. }

• W2044303962 endingPage "115" @default.
• W2044303962 startingPage "106" @default.
• W2044303962 abstract "We have identified cDNA clones encoding a testis-specific poly(A) polymerase, termed TPAP, a candidate molecule responsible for cytoplasmic polyadenylation of preexisting mRNAs in male haploid germ cells. The TPAP gene was most abundantly expressed coincident with the additional elongation of mRNA poly(A) tails in round spermatids. The amino acid sequence of TPAP contained 642 residues, and shared a high degree of identity (86%) with that of a nuclear poly(A) polymerase, PAP II. Despite the sequence conservation of functional elements, including three catalytic Asp residues, an ATP-binding site, and an RNA-binding domain, TPAP lacked an approximately 100-residue C-terminal sequence carrying one of two bipartite-type nuclear localization signals, and part of a Ser/Thr-rich domain found in PAP II. Recombinant TPAP produced by an in vitro transcription/translation system was capable of incorporating the AMP moiety from ATP into an oligo(A)12 RNA primer in the presence of MnCl2. Moreover, an affinity-purified antibody against the 12-residue C-terminal sequence of TPAP recognized a 70-kDa protein in the cytoplasm of spermatogenic cells. These results suggest that TPAP may participate in the additional extension of mRNA poly(A) tails in the cytoplasm of male germ cells, and may play an important role in spermiogenesis, probably through the stabilization of mRNAs." @default.
• W2044303962 created "2016-06-24" @default.
• W2044303962 creator A5005193322 @default.
• W2044303962 creator A5015505072 @default.
• W2044303962 creator A5027904371 @default.
• W2044303962 creator A5030819348 @default.
• W2044303962 creator A5035702067 @default.
• W2044303962 creator A5063610442 @default.
• W2044303962 date "2000-12-01" @default.
• W2044303962 modified "2023-10-14" @default.
• W2044303962 title "Identification of a Novel Isoform of Poly(A) Polymerase, TPAP, Specifically Present in the Cytoplasm of Spermatogenic Cells" @default.
• W2044303962 cites W1483519977 @default.
• W2044303962 cites W1543901357 @default.
• W2044303962 cites W1905440877 @default.
• W2044303962 cites W1936287604 @default.
• W2044303962 cites W1936981955 @default.
• W2044303962 cites W1966006041 @default.
• W2044303962 cites W1969699616 @default.
• W2044303962 cites W1972914977 @default.
• W2044303962 cites W1973505925 @default.
• W2044303962 cites W1981667551 @default.
• W2044303962 cites W1984611669 @default.
• W2044303962 cites W1993256866 @default.
• W2044303962 cites W2008364254 @default.
• W2044303962 cites W2014401973 @default.
• W2044303962 cites W2017669487 @default.
• W2044303962 cites W2019801189 @default.
• W2044303962 cites W2020721543 @default.
• W2044303962 cites W2022555897 @default.
• W2044303962 cites W2028012837 @default.
• W2044303962 cites W2035649423 @default.
• W2044303962 cites W2038534763 @default.
• W2044303962 cites W2040418544 @default.
• W2044303962 cites W2045202900 @default.
• W2044303962 cites W2048146797 @default.
• W2044303962 cites W2052764329 @default.
• W2044303962 cites W2067064841 @default.
• W2044303962 cites W2072177313 @default.
• W2044303962 cites W2079011363 @default.
• W2044303962 cites W2084487914 @default.
• W2044303962 cites W2089784855 @default.
• W2044303962 cites W2091759633 @default.
• W2044303962 cites W2092590107 @default.
• W2044303962 cites W2099159538 @default.
• W2044303962 cites W2103973742 @default.
• W2044303962 cites W2146482087 @default.
• W2044303962 cites W2151971476 @default.
• W2044303962 cites W2169323084 @default.
• W2044303962 cites W218607324 @default.
• W2044303962 cites W2270487047 @default.
• W2044303962 cites W2313256711 @default.
• W2044303962 cites W4243584423 @default.
• W2044303962 cites W4246278761 @default.
• W2044303962 cites W4251911047 @default.
• W2044303962 cites W4293247451 @default.
• W2044303962 doi "https://doi.org/10.1006/dbio.2000.9894" @default.
• W2044303962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11087630" @default.
• W2044303962 hasPublicationYear "2000" @default.
• W2044303962 type Work @default.
• W2044303962 sameAs 2044303962 @default.
• W2044303962 citedByCount "90" @default.
• W2044303962 countsByYear W20443039622012 @default.
• W2044303962 countsByYear W20443039622013 @default.
• W2044303962 countsByYear W20443039622014 @default.
• W2044303962 countsByYear W20443039622015 @default.
• W2044303962 countsByYear W20443039622016 @default.
• W2044303962 countsByYear W20443039622017 @default.
• W2044303962 countsByYear W20443039622018 @default.
• W2044303962 countsByYear W20443039622019 @default.
• W2044303962 countsByYear W20443039622020 @default.
• W2044303962 countsByYear W20443039622021 @default.
• W2044303962 countsByYear W20443039622022 @default.
• W2044303962 crossrefType "journal-article" @default.
• W2044303962 hasAuthorship W2044303962A5005193322 @default.
• W2044303962 hasAuthorship W2044303962A5015505072 @default.
• W2044303962 hasAuthorship W2044303962A5027904371 @default.
• W2044303962 hasAuthorship W2044303962A5030819348 @default.
• W2044303962 hasAuthorship W2044303962A5035702067 @default.
• W2044303962 hasAuthorship W2044303962A5063610442 @default.
• W2044303962 hasBestOaLocation W20443039621 @default.
• W2044303962 hasConcept C101762097 @default.
• W2044303962 hasConcept C104317684 @default.
• W2044303962 hasConcept C105580179 @default.
• W2044303962 hasConcept C142575336 @default.
• W2044303962 hasConcept C150194340 @default.
• W2044303962 hasConcept C153911025 @default.
• W2044303962 hasConcept C190062978 @default.
• W2044303962 hasConcept C55493867 @default.
• W2044303962 hasConcept C64350747 @default.
• W2044303962 hasConcept C67492840 @default.
• W2044303962 hasConcept C82381507 @default.
• W2044303962 hasConcept C86803240 @default.
• W2044303962 hasConcept C95444343 @default.
• W2044303962 hasConceptScore W2044303962C101762097 @default.
• W2044303962 hasConceptScore W2044303962C104317684 @default.
• W2044303962 hasConceptScore W2044303962C105580179 @default.
• W2044303962 hasConceptScore W2044303962C142575336 @default.
• W2044303962 hasConceptScore W2044303962C150194340 @default.

• next