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- W2044315253 abstract ">90 mL/min/1.73 m 2 . Out of 1600 CHD patients, 642 had stage 1 (>90 mL/min/1.73 m 2 ), 864 stage 2 (60‐89 mL/ min/1.73 m 2 ), and 94 stage 3 (30‐59 mL/min/1.73 m 2 ) renal function status, similarly distributed in the 2 treatment groups (structured vs usual care). In multivariate regression, for every 5% of decrease in eGFR vs baseline there was a 10% increase in CVD risk in statin-untreated patients, and with every 5% increase in eGFR there was a 16% reduction in CVD risk in statin-treated patients. 2 If we evaluate patients with stage 2 renal function (n = 864) at baseline, those not treated with a statin had an increased CVD risk (any vascular event at 3 years follow-up) vs treated, after adjusting for 10 covariates including low density lipoprotein cholesterol (hazard ratio [HR]: 1.15, 95% confidence interval [CI]: 1.09‐1.19), compared with stage 1 patients (HR: 1.08, 95% CI: 1.01‐1.16), but a lower risk compared with stage 3 untreated patients (HR: 1.24, 95% CI: 1.17‐1.32). Similarrelationshipswereobservedinprimaryprevention patients with metabolic syndrome participating in the Assessing The Treatment Effect in Metabolic Syndrome Without Perceptible diabeTes (ATTEMPT) study. 3 CVD risk increases as renal function declines even with mildly decreased GFR. These observations justify the characterization in recent guidelines of renal impairment as a high-risk category. 4" @default.
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- W2044315253 date "2012-01-19" @default.
- W2044315253 modified "2023-09-28" @default.
- W2044315253 title "Response to Mildly Decreased Glomerular Filtration Rate Is Associated With Poor Coronary Heart Disease Outcome" @default.
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- W2044315253 doi "https://doi.org/10.1002/clc.21002" @default.
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