FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044315923> ?p ?o ?g. }

• W2044315923 endingPage "1034" @default.
• W2044315923 startingPage "1023" @default.
• W2044315923 abstract "Hedgehog (HH) signalling is involved in the development of numerous embryonic tissues. In humans, germline mutations in hedgehog pathway components cause congenital malformations and somatic mutations are associated with cancers. The basic framework of the HH pathway was elucidated in the fruit fly, Drosophila melanogaster, and this pathway is largely conserved in vertebrates, although some important differences have been noted. The current paradigm of the ‘canonical’ pathway views HH signalling as a series of repressive interactions which culminates in GLI-mediated transcriptional regulation of a variety of cellular processes. Definitions of ‘non-canonical’ signalling stem from examples where the response to HH morphogen deviates from this paradigm and, according to current reports, three general scenarios of non-canonical HH signalling can be defined: (1) Signalling that involves HH pathway components but which is independent of GLI-mediated transcription; (2) Direct interaction of HH signalling components with components of other molecular pathways; and (3) ‘Non-contiguous’ or ‘atypical’ interaction of core HH pathway components with one another. Currently, the evidence supporting non-canonical HH signalling is not conclusive. However, Sonic hedgehog (SHH) has been shown to regulate cell migration and axon guidance in several contexts, and some of these processes are independent of downstream components of the HH pathway, and presumably the transcriptional response to morphogen. Furthermore, biochemical studies have shown that the HH receptor, PTCH1, can directly interact both with Cyclin B1 and caspases, to inhibit cell proliferation and to promote apoptosis, respectively, and that these functions are inhibited in the presence of morphogen. Genetic analysis of orthologues of the HH pathway in nematode worms further supports the notion that PTCH1-related molecules can function independently of other components of the canonical HH pathway, and the phenotypes of mice with point mutations in the Ptch1 gene offer clues as to the processes that non-canonical HH signalling might regulate. While none of these evidences are conclusive, collectively they point to the existence of added complexity in the HH pathway in the form of non-canonical pathways. A major difficulty in studying this problem is that canonical and non-canonical pathways are likely to act in parallel, and so in many situations it will not be possible to implicate non-canonical responses in certain cellular processes simply by excluding a role for the canonical pathway—directed analyses of non-canonical HH signalling are therefore necessary. The aim of this review is to present the cumulative evidence supporting non-canonical HH signalling, with the hope of promoting further enquiry into this area." @default.
• W2044315923 created "2016-06-24" @default.
• W2044315923 creator A5049595108 @default.
• W2044315923 date "2009-07-01" @default.
• W2044315923 modified "2023-10-16" @default.
• W2044315923 title "Hedgehog signalling: Emerging evidence for non-canonical pathways" @default.
• W2044315923 cites W1481472040 @default.
• W2044315923 cites W1539784659 @default.
• W2044315923 cites W1585922331 @default.
• W2044315923 cites W1594815607 @default.
• W2044315923 cites W1604791477 @default.
• W2044315923 cites W1609447875 @default.
• W2044315923 cites W163275813 @default.
• W2044315923 cites W1679992491 @default.
• W2044315923 cites W1821222874 @default.
• W2044315923 cites W1835931275 @default.
• W2044315923 cites W1862020947 @default.
• W2044315923 cites W1944127002 @default.
• W2044315923 cites W1950508909 @default.
• W2044315923 cites W1964793254 @default.
• W2044315923 cites W1966715577 @default.
• W2044315923 cites W1968272674 @default.
• W2044315923 cites W1968717680 @default.
• W2044315923 cites W1969938740 @default.
• W2044315923 cites W1970429418 @default.
• W2044315923 cites W1971060771 @default.
• W2044315923 cites W1971981377 @default.
• W2044315923 cites W1973121483 @default.
• W2044315923 cites W1973922563 @default.
• W2044315923 cites W1975711179 @default.
• W2044315923 cites W1976520395 @default.
• W2044315923 cites W1976551834 @default.
• W2044315923 cites W1977590101 @default.
• W2044315923 cites W1979842763 @default.
• W2044315923 cites W1980591242 @default.
• W2044315923 cites W1981691061 @default.
• W2044315923 cites W1983341583 @default.
• W2044315923 cites W1985671892 @default.
• W2044315923 cites W1986297599 @default.
• W2044315923 cites W1987785417 @default.
• W2044315923 cites W1987833953 @default.
• W2044315923 cites W1990073151 @default.
• W2044315923 cites W1990633759 @default.
• W2044315923 cites W1992872682 @default.
• W2044315923 cites W1997905438 @default.
• W2044315923 cites W1998041465 @default.
• W2044315923 cites W1998347477 @default.
• W2044315923 cites W1998464962 @default.
• W2044315923 cites W1999752916 @default.
• W2044315923 cites W1999871603 @default.
• W2044315923 cites W2000572318 @default.
• W2044315923 cites W2001392109 @default.
• W2044315923 cites W2002158057 @default.
• W2044315923 cites W2002641980 @default.
• W2044315923 cites W2005487923 @default.
• W2044315923 cites W2005536416 @default.
• W2044315923 cites W2009811048 @default.
• W2044315923 cites W2010486747 @default.
• W2044315923 cites W2010863761 @default.
• W2044315923 cites W2012543502 @default.
• W2044315923 cites W2013204587 @default.
• W2044315923 cites W2014254246 @default.
• W2044315923 cites W2015189406 @default.
• W2044315923 cites W2017400416 @default.
• W2044315923 cites W2017846611 @default.
• W2044315923 cites W2018456985 @default.
• W2044315923 cites W2021111269 @default.
• W2044315923 cites W2021193175 @default.
• W2044315923 cites W2022059845 @default.
• W2044315923 cites W2026550373 @default.
• W2044315923 cites W2026621967 @default.
• W2044315923 cites W2026858581 @default.
• W2044315923 cites W2027114253 @default.
• W2044315923 cites W2027740990 @default.
• W2044315923 cites W2028497134 @default.
• W2044315923 cites W2029080338 @default.
• W2044315923 cites W2033234356 @default.
• W2044315923 cites W2038090189 @default.
• W2044315923 cites W2039355845 @default.
• W2044315923 cites W2040633563 @default.
• W2044315923 cites W2040834955 @default.
• W2044315923 cites W2042192373 @default.
• W2044315923 cites W2043216677 @default.
• W2044315923 cites W2044616474 @default.
• W2044315923 cites W2045149956 @default.
• W2044315923 cites W2045190445 @default.
• W2044315923 cites W2048214112 @default.
• W2044315923 cites W2049910739 @default.
• W2044315923 cites W2052694810 @default.
• W2044315923 cites W2053996795 @default.
• W2044315923 cites W2054463240 @default.
• W2044315923 cites W2056661654 @default.
• W2044315923 cites W2059614045 @default.
• W2044315923 cites W2059736161 @default.
• W2044315923 cites W2062235108 @default.
• W2044315923 cites W2064950130 @default.
• W2044315923 cites W2065634301 @default.
• W2044315923 cites W2066353824 @default.

• next