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- W2044319306 abstract "In the past few years, the understanding of microRNA (miRNA) biogenesis, the molecular mechanisms by which miRNAs regulate gene expression, and the functional roles of miRNAs has been expanded. Interestingly, numerous miRNAs are expressed in a spatially and temporally controlled manner in the nervous system, suggesting that their post-transcriptional regulation may be particularly relevant in neural development and function. miRNA studies in neurobiology have shown their involvement in synaptic plasticity and brain diseases. Approaches for manipulating miRNA levels in neuronal cells in vitro and in vivo are described here. Recent applications of miRNA antisense oligonucleotides, miRNA gene knockout and miRNA sponges in neuronal cells are reviewed. Finally, miRNA-based therapies for neurological pathologies related to alterations in miRNA functions are discussed." @default.
- W2044319306 created "2016-06-24" @default.
- W2044319306 creator A5017240509 @default.
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- W2044319306 date "2012-06-01" @default.
- W2044319306 modified "2023-09-23" @default.
- W2044319306 title "Targeting microRNAs in neurons: Tools and perspectives" @default.
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- W2044319306 doi "https://doi.org/10.1016/j.expneurol.2011.10.031" @default.
- W2044319306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22085592" @default.
- W2044319306 hasPublicationYear "2012" @default.
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