Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044320727> ?p ?o ?g. }
- W2044320727 endingPage "22" @default.
- W2044320727 startingPage "16" @default.
- W2044320727 abstract "Purpose of review Due to the dominance of Th1 cytokines in rejection and the ability of Th2 cytokines, particularly IL-4, to inhibit Th1 responses, it has long been held that Th2 cytokines can improve transplant outcomes. Although there is some support for this, there is mounting evidence that IL-4 and Th2 cytokines can promote graft dysfunction. These disparate effects are reviewed. Recent findings The role of Th2 cytokines in graft dysfunction is not necessarily due to promotion of humoral immunity, but is due to their ability to drive T-cell and non-T-cell responses including alternative activation of macrophages. Alternatively, activated macrophages compete with classically activated macrophages for arginine and they are mutually exclusive, analogous to mutual competition between Th1 and Th2 cells. Recent findings also point to two subsets of regulatory T cells (Tregs), each dependent on either Th1 or Th2 cytokines. In addition to its effects on bone marrow-derived cells, IL-4 affects parenchymal cells by signalling through the type II receptor, which consists of the IL-4R alpha chain (IL-4Rα) and the IL-13Rα1, which also binds IL-13. Summary The effects of Th2 cytokines in transplantation depend on their cellular targets, the timing and form of administration and on Th2 cytokine-dependent Tregs." @default.
- W2044320727 created "2016-06-24" @default.
- W2044320727 creator A5008508958 @default.
- W2044320727 creator A5021399262 @default.
- W2044320727 creator A5032249420 @default.
- W2044320727 date "2009-02-01" @default.
- W2044320727 modified "2023-10-15" @default.
- W2044320727 title "Role of IL-4 and Th2 responses in allograft rejection and tolerance" @default.
- W2044320727 cites W1498193433 @default.
- W2044320727 cites W1501543368 @default.
- W2044320727 cites W1502609432 @default.
- W2044320727 cites W1526476464 @default.
- W2044320727 cites W1550495414 @default.
- W2044320727 cites W1561573262 @default.
- W2044320727 cites W1562618544 @default.
- W2044320727 cites W1577909447 @default.
- W2044320727 cites W1582941402 @default.
- W2044320727 cites W1583698670 @default.
- W2044320727 cites W1599375505 @default.
- W2044320727 cites W1655136182 @default.
- W2044320727 cites W1677024991 @default.
- W2044320727 cites W1715352648 @default.
- W2044320727 cites W1861506373 @default.
- W2044320727 cites W1863074823 @default.
- W2044320727 cites W1879781226 @default.
- W2044320727 cites W1942668068 @default.
- W2044320727 cites W1971782694 @default.
- W2044320727 cites W1974618020 @default.
- W2044320727 cites W1977262191 @default.
- W2044320727 cites W1977913178 @default.
- W2044320727 cites W1979130190 @default.
- W2044320727 cites W1981421034 @default.
- W2044320727 cites W1990405721 @default.
- W2044320727 cites W1991585549 @default.
- W2044320727 cites W1998772929 @default.
- W2044320727 cites W2000128077 @default.
- W2044320727 cites W2002726823 @default.
- W2044320727 cites W2009085019 @default.
- W2044320727 cites W2009185272 @default.
- W2044320727 cites W2014999579 @default.
- W2044320727 cites W2015681660 @default.
- W2044320727 cites W2027699993 @default.
- W2044320727 cites W2030453793 @default.
- W2044320727 cites W2033818911 @default.
- W2044320727 cites W2034699026 @default.
- W2044320727 cites W2034922007 @default.
- W2044320727 cites W2035876896 @default.
- W2044320727 cites W2036396320 @default.
- W2044320727 cites W2038689279 @default.
- W2044320727 cites W2042838407 @default.
- W2044320727 cites W2043046650 @default.
- W2044320727 cites W2045346081 @default.
- W2044320727 cites W2050042205 @default.
- W2044320727 cites W2058062220 @default.
- W2044320727 cites W2065434799 @default.
- W2044320727 cites W2067515152 @default.
- W2044320727 cites W2067752500 @default.
- W2044320727 cites W2082127519 @default.
- W2044320727 cites W2082508872 @default.
- W2044320727 cites W2088031551 @default.
- W2044320727 cites W2097811455 @default.
- W2044320727 cites W2099712159 @default.
- W2044320727 cites W2102084027 @default.
- W2044320727 cites W2107113286 @default.
- W2044320727 cites W2109995045 @default.
- W2044320727 cites W2116803825 @default.
- W2044320727 cites W2117631259 @default.
- W2044320727 cites W2118102164 @default.
- W2044320727 cites W2121438383 @default.
- W2044320727 cites W2123511115 @default.
- W2044320727 cites W2130622801 @default.
- W2044320727 cites W2136707854 @default.
- W2044320727 cites W2140612321 @default.
- W2044320727 cites W2142546441 @default.
- W2044320727 cites W2144120552 @default.
- W2044320727 cites W2147098499 @default.
- W2044320727 cites W2147858215 @default.
- W2044320727 cites W2156716608 @default.
- W2044320727 cites W2157278565 @default.
- W2044320727 cites W2160097418 @default.
- W2044320727 cites W2161329415 @default.
- W2044320727 cites W2162336293 @default.
- W2044320727 cites W235572530 @default.
- W2044320727 cites W2792745638 @default.
- W2044320727 cites W4313347774 @default.
- W2044320727 cites W57595804 @default.
- W2044320727 doi "https://doi.org/10.1097/mot.0b013e32831ebdf5" @default.
- W2044320727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19337141" @default.
- W2044320727 hasPublicationYear "2009" @default.
- W2044320727 type Work @default.
- W2044320727 sameAs 2044320727 @default.
- W2044320727 citedByCount "59" @default.
- W2044320727 countsByYear W20443207272012 @default.
- W2044320727 countsByYear W20443207272013 @default.
- W2044320727 countsByYear W20443207272014 @default.
- W2044320727 countsByYear W20443207272016 @default.
- W2044320727 countsByYear W20443207272017 @default.
- W2044320727 countsByYear W20443207272018 @default.