Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044329412> ?p ?o ?g. }
- W2044329412 endingPage "e94934" @default.
- W2044329412 startingPage "e94934" @default.
- W2044329412 abstract "Sepsis rapidly activates the host inflammatory response and acute phase response. Severe sepsis, complicated by multiple organ failure, is associated with overwhelming inflammation and high mortality. We previously observed that zinc (Zn) deficiency significantly increases mortality in a mouse model of polymicrobial sepsis due to over-activation of the inflammatory response. In order to identify potential mechanisms that account for Zn-responsive effects, we generated whole exome expression profiles from the lung tissue of septic mice that were maintained on Zn modified diets. Based on systems analysis, we observed that Zn deficiency enhances the acute phase response and particularly the JAK-STAT3 pathway, resulting in increased serum amyloid A production. In vitro studies of primary hepatocytes and HepG2 cells substantiated that Zn-deficiency augments serum amyloid A production through up-regulation of the JAK-STAT3 and NF-κB pathways. In contrast, Zn inhibited STAT3 activation through the up-regulation of SHP1 activity. Collectively, these findings demonstrate that Zn deficiency enhances the acute phase response through up-regulation of the JAK-STAT3 pathway, thereby perpetuating increased inflammation that may lead to increased morbidity and mortality in response to sepsis." @default.
- W2044329412 created "2016-06-24" @default.
- W2044329412 creator A5007740257 @default.
- W2044329412 creator A5008938971 @default.
- W2044329412 creator A5015697739 @default.
- W2044329412 creator A5015986486 @default.
- W2044329412 creator A5048499133 @default.
- W2044329412 creator A5049014232 @default.
- W2044329412 creator A5087538819 @default.
- W2044329412 date "2014-04-14" @default.
- W2044329412 modified "2023-10-18" @default.
- W2044329412 title "Zinc Regulates the Acute Phase Response and Serum Amyloid A Production in Response to Sepsis through JAK-STAT3 Signaling" @default.
- W2044329412 cites W1512960324 @default.
- W2044329412 cites W1747551678 @default.
- W2044329412 cites W1855316965 @default.
- W2044329412 cites W1859796131 @default.
- W2044329412 cites W1869433473 @default.
- W2044329412 cites W1943607432 @default.
- W2044329412 cites W1946507092 @default.
- W2044329412 cites W1966143451 @default.
- W2044329412 cites W1977905350 @default.
- W2044329412 cites W1978298108 @default.
- W2044329412 cites W1980091755 @default.
- W2044329412 cites W1981243375 @default.
- W2044329412 cites W1985431145 @default.
- W2044329412 cites W1992075095 @default.
- W2044329412 cites W1995312949 @default.
- W2044329412 cites W2011006768 @default.
- W2044329412 cites W2020685739 @default.
- W2044329412 cites W2024358287 @default.
- W2044329412 cites W2046540215 @default.
- W2044329412 cites W2046692671 @default.
- W2044329412 cites W2047812782 @default.
- W2044329412 cites W2050100088 @default.
- W2044329412 cites W2065405978 @default.
- W2044329412 cites W2067761476 @default.
- W2044329412 cites W2068525579 @default.
- W2044329412 cites W2074662949 @default.
- W2044329412 cites W2075840772 @default.
- W2044329412 cites W2081534074 @default.
- W2044329412 cites W2081748503 @default.
- W2044329412 cites W2085410330 @default.
- W2044329412 cites W2096254377 @default.
- W2044329412 cites W2099155952 @default.
- W2044329412 cites W2102050228 @default.
- W2044329412 cites W2103254653 @default.
- W2044329412 cites W2104743514 @default.
- W2044329412 cites W2104825124 @default.
- W2044329412 cites W2114216755 @default.
- W2044329412 cites W2120817194 @default.
- W2044329412 cites W2127854030 @default.
- W2044329412 cites W2129991688 @default.
- W2044329412 cites W2132471916 @default.
- W2044329412 cites W2137082708 @default.
- W2044329412 cites W2146321139 @default.
- W2044329412 cites W2152122395 @default.
- W2044329412 cites W2153291891 @default.
- W2044329412 cites W2154571798 @default.
- W2044329412 cites W2155136631 @default.
- W2044329412 cites W2157045527 @default.
- W2044329412 cites W2161688851 @default.
- W2044329412 cites W2163458407 @default.
- W2044329412 cites W2170257664 @default.
- W2044329412 cites W2170285826 @default.
- W2044329412 cites W2317184793 @default.
- W2044329412 cites W2324640604 @default.
- W2044329412 cites W3216995939 @default.
- W2044329412 doi "https://doi.org/10.1371/journal.pone.0094934" @default.
- W2044329412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3986341" @default.
- W2044329412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24732911" @default.
- W2044329412 hasPublicationYear "2014" @default.
- W2044329412 type Work @default.
- W2044329412 sameAs 2044329412 @default.
- W2044329412 citedByCount "31" @default.
- W2044329412 countsByYear W20443294122014 @default.
- W2044329412 countsByYear W20443294122015 @default.
- W2044329412 countsByYear W20443294122016 @default.
- W2044329412 countsByYear W20443294122017 @default.
- W2044329412 countsByYear W20443294122018 @default.
- W2044329412 countsByYear W20443294122019 @default.
- W2044329412 countsByYear W20443294122020 @default.
- W2044329412 countsByYear W20443294122021 @default.
- W2044329412 countsByYear W20443294122022 @default.
- W2044329412 crossrefType "journal-article" @default.
- W2044329412 hasAuthorship W2044329412A5007740257 @default.
- W2044329412 hasAuthorship W2044329412A5008938971 @default.
- W2044329412 hasAuthorship W2044329412A5015697739 @default.
- W2044329412 hasAuthorship W2044329412A5015986486 @default.
- W2044329412 hasAuthorship W2044329412A5048499133 @default.
- W2044329412 hasAuthorship W2044329412A5049014232 @default.
- W2044329412 hasAuthorship W2044329412A5087538819 @default.
- W2044329412 hasBestOaLocation W20443294121 @default.
- W2044329412 hasConcept C142724271 @default.
- W2044329412 hasConcept C14522933 @default.
- W2044329412 hasConcept C203014093 @default.
- W2044329412 hasConcept C2776914184 @default.
- W2044329412 hasConcept C2776928490 @default.
- W2044329412 hasConcept C2778384902 @default.