FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044332414> ?p ?o ?g. }

• W2044332414 endingPage "835" @default.
• W2044332414 startingPage "826" @default.
• W2044332414 abstract "No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Sep 2000EXPRESSION OF E-, P-, N-CADHERINS AND CATENINS IN HUMAN BLADDER CARCINOMA CELL LINES AGNÉS MIALHE, GÉRALDINE LEVACHER, PIERRE CHAMPELOVIER, VÉRONIQUE MARTEL, MIREILLE SERRES, KAREN KNUDSEN, and DANIEL SEIGNEURIN AGNÉS MIALHEAGNÉS MIALHE More articles by this author , GÉRALDINE LEVACHERGÉRALDINE LEVACHER More articles by this author , PIERRE CHAMPELOVIERPIERRE CHAMPELOVIER More articles by this author , VÉRONIQUE MARTELVÉRONIQUE MARTEL More articles by this author , MIREILLE SERRESMIREILLE SERRES More articles by this author , KAREN KNUDSENKAREN KNUDSEN More articles by this author , and DANIEL SEIGNEURINDANIEL SEIGNEURIN More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)67322-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Cadherins are cell surface glycoproteins that mediate Ca2+-dependent, homophilic cell-cell adhesion. The classical cadherins, E-, P- and N-cadherins, are known to self-associate from their extracellular domain, while their cytoplasmic domain interacts with either β-catenin or plakoglobin (γ-catenin), which in turn is bound to α-catenin that links the complex to the actin cytoskeleton. The aim of the present study was to analyze the expression of E-, P- and N-cadherins and catenins in human bladder carcinoma cells. Materials and Methods: Five human bladder carcinoma cell lines, representing a variety of differentiation states, were grown in cell culture. We performed a cell aggregation assay, specific for biological cadherin activity. The expression of cadherins and catenins was analyzed by immunocytochemistry, Western blotting and RT-PCR. The interactions between cadherins and catenins were assessed by immunoprecipitation. Results: We observed a reduced E-cadherin expression in the poorly differentiated and invasive-tumor derived cells. Interestingly, immunofluorescence study reveals the persistent localization of catenins at intercellular contacts in two E-cadherin deficient cell lines (T24 and TCCSUP) which yet exhibit an epithelial-like morphology and a calcium-dependent adhesive capacity. This suggests that other cadherin(s) are expressed in these both cell lines. P-cadherin, another epithelial cadherin, is expressed only in E-cadherin positive cells. On the other hand, N-cadherin is present at cell-cell borders in the very anaplastic cell lines, T24 and TCCSUP, and is able to link β-catenin or plakoglobin. Conclusion: These results indicate that N-cadherin may participate in intercellular adhesion, while facilitating bladder tumorigenesis. References 1 : Cadherin cell adhesion receptors as a morphogenetic regulator. Science1991; 251: 1451. Crossref, Medline, Google Scholar 2 : The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development1988; 102: 639. Crossref, Medline, Google Scholar 3 : Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell1996; 84: 345. Google Scholar 4 : Cell adhesion and signal transduction: the Armadillo connection. Trends Cell Biol1995; 5: 224. Google Scholar 5 : E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms. J Cell Sci1997; 110: 345. Google Scholar 6 : Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. Cancer Res1989; 49: 2128. Google Scholar 7 : Multiple cadherins are expressed in human fibroblasts. Biochem Biophys Res Comm1997; 235: 355. Google Scholar 8 : A role for the C2+-dependent adhesion molecule, N-cadherin, in myoblast interaction during myogenesis. Exp Cell Res1990; 188: 175. Google Scholar 9 : Extrajunctional distribution of N-cadherin in cultured human endothelial cells. J Cell Sci1992; 102: 7. Google Scholar 10 : The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J1989; 8: 1711. Google Scholar 11 : Cell binding function of E-cadherin is regulated by the cytoplasmic domain. EMBO J1988; 7: 3679. Google Scholar 12 : Prognostic value of cadherin-associated molecules (α-, β-, and γ-catenins and p120cas) in bladder tumors. Cancer Res1996; 56: 4154. Google Scholar 13 : Expression of E-cadherin and α-, β- and γ-catenins in human bladder carcinomas: are they good prognostic factors?. Invasion Metastasis1997; 17: 124. Google Scholar 14 : Karyotype and FISH analysis of a newly established cell line derived from a human bladder carcinoma. Cancer Genet Cytogenet1993; 67: 101. Google Scholar 15 : Interaction of α-actinin with the N-cadherin/catenin cell-cell adhesion complex via α-catenin. J Cell Biol1995; 130: 67. Google Scholar 16 : Functional correlation between cell adhesive properties and some cell surface proteins. J Cell Biol1977; 75: 464. Google Scholar 17 : P- and E-cadherin are in separate complexes in cells expressing both cadherins. Exp Cell Res1993; 207: 252. Google Scholar 18 : L-CAM expression induces fibroblast-epidermoid transition in squamous carcinoma cells and down-regulates the endogenous N-cadherin. J Cell Sci1998; 111: 1005. Google Scholar 19 : Expression of N-cadherin by human squamous carcinoma cells induces a scaterred fibroblastic phenotype with disrupted cell-cell adhesion. J Cell Biol1996; 135: 1643. Google Scholar 20 : Human bladder carcinoma cell lines as indicators of oncogenic change relevant to urothelial neoplastic progression. Br J Cancer1995; 72: 683. Google Scholar 21 : Loss of human E-cadherin (ECD) correlated with invasiveness of transitional cell cancer in the renal pelvis, ureter and urinary bladder. Cancer Lett1996; 103: 11. Google Scholar 22 : Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res1993; 53: 1696. Google Scholar 23 : Loss of membranous E-cadherin expression in pancreatic cancer: correlation with lymph node metastasis, high grade and advanced stage. J Pathol1994; 174: 243. Google Scholar 24 : Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res1994; 54: 3929. Google Scholar 25 : Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumors. Cancer Res1993; 53: 3241. Medline, Google Scholar 26 : E-cadherin expression in bladder cancer using formalin-fixed, paraffin-embedded tissues: correlation with histopathological grade, tumour stage and survival. Int J Cancer1995; 64: 367. Crossref, Medline, Google Scholar 27 : Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas. Cancer Res1994; 54: 3120. Medline, Google Scholar 28 : β-catenin - one player, two games. Nature Genet1997; 16: 9. Google Scholar 29 : A truncated β-catenin disrupts the interaction between E-cadherin and α-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines. Cancer Res1994; 54: 6282. Google Scholar 30 : The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression. Cell1991; 65: 849. Google Scholar 31 : Suppression of tumorigenicity by plakoglobin: an augmenting effect of N-cadherin. J Cell Biol1996; 133: 199. Google Scholar 32 : N-cadherin promotes adhesion between invasive breast cancer cells and the stroma. Cell Adhes Comm1997; 4: 399. Google Scholar 33 : Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization. J Cell Biol1998; 140: 1475. Google Scholar 34 : A role for cadherins in cellular signaling and differentiation. J Cell Biochem1998; 31: 168. Google Scholar 35 : A role for the FGF receptor in the axonal growth response stimulated by cell adhesion molecules?. Cell Adhes Comm1996; 3: 441. Google Scholar 36 : N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol1999; 147: 631. Google Scholar From the Laboratory of Cell Migration and Tumoral Invasion, Research Group on Bladder Tumors, Albert Bonniot Institute, Joseph-Fourier University, the Department of Cytology, University Hospital of Grenoble, Grenoble, France, and UMR CNRS/UJF 5538, LEDAC, Albert Bonniot Institute, Joseph-Fourier University, Grenoble, France, INSERM U346, Department of Dermatology, E. Herriot Hospital, Lyon, France, and the Lankenau Medical Research Center, Wynnewood, Pennsylvania© 2000 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 164Issue 3 Part 1September 2000Page: 826-835 Advertisement Copyright & Permissions© 2000 by American Urological Association, Inc.KeywordscateninsE-cadherinbladder cancerN-cadherinP-cadherinMetricsAuthor Information AGNÉS MIALHE More articles by this author GÉRALDINE LEVACHER More articles by this author PIERRE CHAMPELOVIER More articles by this author VÉRONIQUE MARTEL More articles by this author MIREILLE SERRES More articles by this author KAREN KNUDSEN More articles by this author DANIEL SEIGNEURIN More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
• W2044332414 created "2016-06-24" @default.
• W2044332414 creator A5015428219 @default.
• W2044332414 creator A5020951665 @default.
• W2044332414 creator A5031608024 @default.
• W2044332414 creator A5033989574 @default.
• W2044332414 creator A5055697610 @default.
• W2044332414 creator A5064193156 @default.
• W2044332414 creator A5067787952 @default.
• W2044332414 date "2000-09-01" @default.
• W2044332414 modified "2023-10-16" @default.
• W2044332414 title "EXPRESSION OF E-, P-, N-CADHERINS AND CATENINS IN HUMAN BLADDER CARCINOMA CELL LINES" @default.
• W2044332414 cites W153332747 @default.
• W2044332414 cites W1534652806 @default.
• W2044332414 cites W1971873096 @default.
• W2044332414 cites W1972027926 @default.
• W2044332414 cites W1975355340 @default.
• W2044332414 cites W1981752846 @default.
• W2044332414 cites W1986403312 @default.
• W2044332414 cites W1991076778 @default.
• W2044332414 cites W1992706018 @default.
• W2044332414 cites W2011045381 @default.
• W2044332414 cites W2022572663 @default.
• W2044332414 cites W2038126788 @default.
• W2044332414 cites W2039375742 @default.
• W2044332414 cites W2052987836 @default.
• W2044332414 cites W2063284524 @default.
• W2044332414 cites W2066551582 @default.
• W2044332414 cites W2076959105 @default.
• W2044332414 cites W2093463471 @default.
• W2044332414 cites W2102877711 @default.
• W2044332414 cites W2105015609 @default.
• W2044332414 cites W2111072594 @default.
• W2044332414 cites W2118613169 @default.
• W2044332414 cites W2122507780 @default.
• W2044332414 cites W2125197879 @default.
• W2044332414 cites W2127121861 @default.
• W2044332414 cites W2130837149 @default.
• W2044332414 cites W2137581290 @default.
• W2044332414 cites W2149683627 @default.
• W2044332414 cites W2154228322 @default.
• W2044332414 cites W2172160601 @default.
• W2044332414 cites W2413607585 @default.
• W2044332414 cites W2460109131 @default.
• W2044332414 doi "https://doi.org/10.1016/s0022-5347(05)67322-3" @default.
• W2044332414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10953163" @default.
• W2044332414 hasPublicationYear "2000" @default.
• W2044332414 type Work @default.
• W2044332414 sameAs 2044332414 @default.
• W2044332414 citedByCount "40" @default.
• W2044332414 countsByYear W20443324142013 @default.
• W2044332414 countsByYear W20443324142014 @default.
• W2044332414 countsByYear W20443324142015 @default.
• W2044332414 countsByYear W20443324142016 @default.
• W2044332414 countsByYear W20443324142017 @default.
• W2044332414 countsByYear W20443324142019 @default.
• W2044332414 countsByYear W20443324142021 @default.
• W2044332414 countsByYear W20443324142022 @default.
• W2044332414 countsByYear W20443324142023 @default.
• W2044332414 crossrefType "journal-article" @default.
• W2044332414 hasAuthorship W2044332414A5015428219 @default.
• W2044332414 hasAuthorship W2044332414A5020951665 @default.
• W2044332414 hasAuthorship W2044332414A5031608024 @default.
• W2044332414 hasAuthorship W2044332414A5033989574 @default.
• W2044332414 hasAuthorship W2044332414A5055697610 @default.
• W2044332414 hasAuthorship W2044332414A5064193156 @default.
• W2044332414 hasAuthorship W2044332414A5067787952 @default.
• W2044332414 hasConcept C121608353 @default.
• W2044332414 hasConcept C126322002 @default.
• W2044332414 hasConcept C137620995 @default.
• W2044332414 hasConcept C142724271 @default.
• W2044332414 hasConcept C143998085 @default.
• W2044332414 hasConcept C1491633281 @default.
• W2044332414 hasConcept C149402561 @default.
• W2044332414 hasConcept C2777546739 @default.
• W2044332414 hasConcept C2780352672 @default.
• W2044332414 hasConcept C2909082478 @default.
• W2044332414 hasConcept C2992454250 @default.
• W2044332414 hasConcept C30145163 @default.
• W2044332414 hasConcept C502942594 @default.
• W2044332414 hasConcept C54355233 @default.
• W2044332414 hasConcept C62478195 @default.
• W2044332414 hasConcept C71924100 @default.
• W2044332414 hasConcept C86803240 @default.
• W2044332414 hasConcept C95444343 @default.
• W2044332414 hasConceptScore W2044332414C121608353 @default.
• W2044332414 hasConceptScore W2044332414C126322002 @default.
• W2044332414 hasConceptScore W2044332414C137620995 @default.
• W2044332414 hasConceptScore W2044332414C142724271 @default.
• W2044332414 hasConceptScore W2044332414C143998085 @default.
• W2044332414 hasConceptScore W2044332414C1491633281 @default.
• W2044332414 hasConceptScore W2044332414C149402561 @default.
• W2044332414 hasConceptScore W2044332414C2777546739 @default.
• W2044332414 hasConceptScore W2044332414C2780352672 @default.
• W2044332414 hasConceptScore W2044332414C2909082478 @default.
• W2044332414 hasConceptScore W2044332414C2992454250 @default.
• W2044332414 hasConceptScore W2044332414C30145163 @default.
• W2044332414 hasConceptScore W2044332414C502942594 @default.

• next